Abstract Aims Altered Ca2+ handling in atrial fibrillation (AF) has been associated with
dysregulated protein phosphatase 1 (PP1) and subcellular heterogeneities in protein …

Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia and has a significant impact on
morbidity and mortality. Current antiarrhythmic drugs for AF suffer from limited safety and …

Introduction Abnormal calcium signaling between organelles such as the sarcoplasmic
reticulum (SR), mitochondria and lysosomes is a key feature of heart diseases. Calcium …

Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation (AF). The
mechanisms underlying DM-associated AF are unclear. AF and DM are both related to …

Background Atrial fibrillation (AF) is the most common arrhythmia in clinical practice and is a
potential cause of thromboembolic events. AF induces significant changes in the …

Atrial fibrillation (AF) is an irregular heart rhythm, characterised by chaotic atrial activation,
which is promoted by remodelling. Once initiated, AF can also propagate the progression of …

Objective We aimed to assess the effect of SGLT2i on arrhythmias by conducting a meta-
analysis using data from randomized controlled trials (RCTs). Background Sodium-glucose …

Aims The arrhythmogenic mechanisms of atrial fibrillation (AF) that are induced by acute
inflammation, such as postoperative AF, are not well understood. We investigated the acute …

The amount and timing of Ca 2+ release from the sarcoplasmic reticulum (SR) during
cardiac cycle are the main determinants of cardiac contractility. Reversible phosphorylation …

Abstract Aims Abnormal intracellular calcium (Ca2+) handling contributes to the progressive
nature of atrial fibrillation (AF), the most common sustained cardiac arrhythmia. Evidence in …