Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data

MJ Zhang, K Hou, KK Dey, S Sakaue, KA Jagadeesh… - Nature …, 2022 - nature.com
Single-cell RNA sequencing (scRNA-seq) provides unique insights into the pathology and
cellular origin of disease. We introduce single-cell disease relevance score (scDRS), an …
被引用次数：78 相关文章

Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data

MJ Zhang, K Hou, KK Dey, S Sakaue, KA Jagadeesh… - bioRxiv, 2021 - biorxiv.org
Gene expression at the individual cell-level resolution, as quantified by single-cell RNA-
sequencing (scRNA-seq), can provide unique insights into the pathology and cellular origin …

Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data

J Zhang, K Hou, K Dey, S Sakaue, K Jagadeesh… - 2021 - dash.harvard.edu
Gene expression at the individual cell-level resolution, as quantified by single-cell RNA-
sequencing (scRNA-seq), can provide unique insights into the pathology and cellular origin …

Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data

MJ Zhang, K Hou, KK Dey, S Sakaue, KA Jagadeesh… - paper.sciencenet.cn
Single-cell RNA sequencing (scRNA-seq) provides unique insights into the pathology and
cellular origin of disease. We introduce single-cell disease relevance score (scDRS), an …
[HTML] nih.gov

[HTML][HTML] Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data

MJ Zhang, K Hou, KK Dey, S Sakaue… - Nature …, 2022 - ncbi.nlm.nih.gov
Single-cell RNA-sequencing (scRNA-seq) provides unique insights into the pathology and
cellular origin of disease. We introduce scDRS, an approach that links scRNA-seq with …

Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data.

MJ Zhang, K Hou, KK Dey, S Sakaue… - Nature …, 2022 - escholarship.org
Single-cell RNA sequencing (scRNA-seq) provides unique insights into the pathology and
cellular origin of disease. We introduce single-cell disease relevance score (scDRS), an …

Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data

M Zhang, K Hou, B Pasaniuc, AL Price, K Dey… - 2021 - researchsquare.com
Gene expression at the individual cell-level resolution, as quantified by single-cell RNA-
sequencing (scRNA-seq), can provide unique insights into the pathology and cellular origin …

Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data.

MJ Zhang, K Hou, KK Dey, S Sakaue… - Nature …, 2022 - europepmc.org
Single-cell RNA-sequencing (scRNA-seq) provides unique insights into the pathology and
cellular origin of disease. We introduce scDRS, an approach that links scRNA-seq with …

Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data

MJ Zhang, K Hou, KK Dey, S Sakaue… - Nature …, 2022 - pubmed.ncbi.nlm.nih.gov
Single-cell RNA sequencing (scRNA-seq) provides unique insights into the pathology and
cellular origin of disease. We introduce single-cell disease relevance score (scDRS), an …
[PDF] archive.org

[PDF][PDF] Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data

M Zhang, K Hou, B Pasaniuc, AL Price, K Dey… - scholar.archive.org
The mechanisms through which risk variants identified by genome-wide association studies
(GWASs) impact critical tissues and 41 cell types are largely unknown1, 2; identifying these …