Endo-and exocytosis proceed through a highly strained membrane fusion pore topology
regardless of the aiding protein machinery. The membrane's lipid components bias fusion …

SNARE-mediated membrane fusion proceeds via the formation of a fusion pore. This
intermediate structure is highly dynamic and can flicker between open and closed states. In …

To establish the validity of continuum mechanics models quantitatively for the analysis of
membrane remodeling processes, we compare the shape and energies of the membrane …

Cholesterol is essential for exocytosis in secretory cells, but the exact molecular mechanism
by which it facilitates exocytosis is largely unknown. Distinguishing contributions from the …

Cholesterol is a major component of biological membranes and is known to affect vesicle
fusion. However, the mechanism by which cholesterol modulates SNARE-dependent …

Cholesterol-rich lipid rafts are found to facilitate membrane fusion, central to processes like
viral entry, fertilization, and neurotransmitter release. While the fusion process involves local …

Flickering of fusion pores during exocytotic release of hormones and neurotransmitters is
well documented, but without assays that use biochemically defined components and …

Publisher Summary This chapter describes the recent contribution of computer simulation
approaches to unravel the molecular details of membrane fusion. Over the past decade …

Membrane fusion is at the heart of eukaryotic cell life. Carefully regulated membrane fusion
is required for cell compartmentalization, for the import of large molecules into the cell, and …

Membrane fusion is a key event in vesicular trafficking in every cell, and many fusion-related
proteins have been identified. However, how the actual fusion event occurs has not been …