Curvature-based sorting of eight lipid types in asymmetric buckled plasma membrane models

EA Cino, DP Tieleman - Biophysical Journal, 2022 - cell.com
Curvature is a fundamental property of biological membranes and has essential roles in
cellular function. Bending of membranes can be induced by their lipid and protein …

Curvature-induced lipid sorting beyond the critical packing parameter

M Konig, R de Vries, F Grunewald, SJ Marrink… - bioRxiv, 2023 - biorxiv.org
Over the last few decades, the spatial organization of biomembranes has received a lot of
attention. With the fluid mosaic model, Singer and Nicolson proposed that biomembranes …

Changes in lipid density induce membrane curvature

AJ de Jesus, N Kastelowitz, H Yin - RSC advances, 2013 - pubs.rsc.org
Highly curved bilayer lipid membranes make up the shell of many intra-and extracellular
compartments, including organelles and vesicles. Using all-atom molecular dynamics …

Coarse-grained simulations of branched bilayer membranes: effects of cholesterol-dependent phase separation on curvature-driven lipid sorting

M Nishizawa, K Nishizawa - Journal of Biophysical …, 2011 - research.send4journal.com
Our recent coarse-grained (CG) molecular dynamics (MD) simulations of membranes with a
hemifused-ribbon (λ-shaped) geometry showed curvature-driven demixing leading to enrich …

Interplay between curvature and lateral organization of lipids and peptides/proteins in model membranes

QY Wu, Q Liang - Langmuir, 2014 - ACS Publications
Membrane curvature plays a crucial role in the realization of many cellular membrane
functions such as signaling and trafficking. Here, using coarse-grained molecular dynamics …

Exploring the Properties of Curved Lipid Membranes: Comparative Analysis of Atomistic and Coarse-Grained Force Fields

M Domanska, P Setny - The Journal of Physical Chemistry B, 2024 - ACS Publications
Curvature emerges as a fundamental membrane characteristic crucial for diverse biological
processes, including vesicle formation, cell signaling, and membrane trafficking …

Exploring membrane asymmetry and its effects on membrane proteins

G Pabst, S Keller - Trends in Biochemical Sciences, 2024 - cell.com
Plasma membranes utilize free energy to maintain highly asymmetric, non-equilibrium
distributions of lipids and proteins between their two leaflets. In this review we discuss recent …

Curvature Footprints of Transmembrane Proteins in Simulations with the Martini Force Field

EA Cino, DP Tieleman - The Journal of Physical Chemistry B, 2024 - ACS Publications
Membranes play essential roles in biological systems and are tremendously diverse in the
topologies and chemical and elastic properties that define their functions. In many cases, a …

Curvature‐induced sorting of lipids in plasma membrane tethers

S Baoukina, HI Ingólfsson, SJ Marrink… - Advanced Theory and …, 2018 - Wiley Online Library
Membrane curvature controls the spatial organization and activity of cells. Lipid sorting in
cell membranes can be explained by matching lipid molecular shape to regions of different …

[HTML][HTML] The influence of solid scaffolds on flat and curved lipid membranes

DH De Jong, A Heuer - AIP Advances, 2017 - pubs.aip.org
Solid-supported membranes have become a common tool to study lipid membrane
properties in a controlled environment. One particular example is the study of membrane …