The mammalian liver tightly regulates its free cysteine pool, and intracellular cysteine in rat
liver is maintained between 20 and 100 nmol/g even when sulfur amino acid intakes are …

Cysteine catabolism in mammals is dependent upon cysteine dioxygenase (CDO), an
enzyme that adds molecular oxygen to the sulfur of cysteine, converting the thiol to a sulfinic …

Two hepatic enzymes, cysteine dioxygenase (CDO) and γ-glutamylcysteine synthetase
(GCS), play important regulatory roles in the response of cysteine metabolism to changes in …

In liver, cysteine dioxygenase (CDO), cysteinesulfinate decarboxylase (CSD), and γ-
glutamylcysteine synthetase (GCS) play important regulatory roles in the metabolism of …

Mammalian metabolism of ingested cysteine is conducted principally within the liver. The
liver tightly regulates its intracellular cysteine pool to keep levels high enough to meet the …

Little is known about mechanisms of regulation of cysteine dioxygenase (CDO), γ-
glutamylcysteine synthetase (GCS), and cysteine-sulfinate decarboxylase (CSDC) in …

Cysteine homeostasis is dependent on the regulation of cysteine dioxygenase (CDO) in
response to changes in sulfur amino acid intake. CDO oxidizes cysteine to cysteinesulfinate …

To determine the role of nonsulfur vs. sulfur amino acids in regulation of cysteine
metabolism, rats were fed a basal diet or diets supplemented with a mixture of nonsulfur …

Glutathione (γ-glutamyl-cysteinyl-glycine; GSH) is the most abundant low-molecular-weight
thiol, and GSH/glutathione disulfide is the major redox couple in animal cells. The synthesis …

The first-pass metabolism of dietary sulfur amino acids by the liver and the robust
upregulation of hepatic cysteine dioxygenase activity in response to an increase in dietary …