[HTML][HTML] Altered hippocampal-prefrontal communication during anxiety-related avoidance in mice deficient for the autism-associated gene Pogz
MM Cunniff, E Markenscoff-Papadimitriou, J Ostrowski… - Elife, 2020 - elifesciences.org
Many genes have been linked to autism. However, it remains unclear what long-term
changes in neural circuitry result from disruptions in these genes, and how these circuit …
changes in neural circuitry result from disruptions in these genes, and how these circuit …
[HTML][HTML] Disruption of an evolutionarily novel synaptic expression pattern in autism
Cognitive defects in autism spectrum disorder (ASD) include socialization and
communication: key behavioral capacities that separate humans from other species. Here …
communication: key behavioral capacities that separate humans from other species. Here …
Identifying specific prefrontal neurons that contribute to autism-associated abnormalities in physiology and social behavior
Functional imaging and gene expression studies both implicate the medial prefrontal cortex
(mPFC), particularly deep-layer projection neurons, as a potential locus for autism …
(mPFC), particularly deep-layer projection neurons, as a potential locus for autism …
Putative microcircuit-level substrates for attention are disrupted in mouse models of autism
Background Deep layer excitatory circuits in the prefrontal cortex represent the strongest
locus for genetic convergence in autism, but specific abnormalities within these circuits that …
locus for genetic convergence in autism, but specific abnormalities within these circuits that …
Regulation of autism-relevant behaviors by cerebellar–prefrontal cortical circuits
Cerebellar dysfunction has been demonstrated in autism spectrum disorders (ASDs);
however, the circuits underlying cerebellar contributions to ASD-relevant behaviors remain …
however, the circuits underlying cerebellar contributions to ASD-relevant behaviors remain …
[HTML][HTML] Abnormal fear conditioning and amygdala processing in an animal model of autism
A core feature of autism spectrum disorders is the impairment in social interactions. Among
other brain regions, a deficit in amygdala processing has been suggested to underlie this …
other brain regions, a deficit in amygdala processing has been suggested to underlie this …
[HTML][HTML] Gene-environment interaction counterbalances social impairment in mouse models of autism
JW Kim, K Park, RJ Kang, EL Gonzales, HA Oh… - Scientific reports, 2019 - nature.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social
communication deficits and repetitive/restricted behaviors. Although gene-environment …
communication deficits and repetitive/restricted behaviors. Although gene-environment …
[HTML][HTML] Pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice
Several genes implicated in autism spectrum disorder (ASD) are chromatin regulators,
including POGZ. The cellular and molecular mechanisms leading to ASD impaired social …
including POGZ. The cellular and molecular mechanisms leading to ASD impaired social …
[HTML][HTML] Common circuit defect of excitatory-inhibitory balance in mouse models of autism
One unifying explanation for the complexity of Autism Spectrum Disorders (ASD) may lie in
the disruption of excitatory/inhibitory (E/I) circuit balance during critical periods of …
the disruption of excitatory/inhibitory (E/I) circuit balance during critical periods of …
Defining the cognitive phenotype of autism
Although much progress has been made in determining the cognitive profile of strengths
and weaknesses that characterise individuals with autism spectrum disorders (ASDs), there …
and weaknesses that characterise individuals with autism spectrum disorders (ASDs), there …