Loss of maternal UBE3A causes Angelman syndrome (AS), a neurodevelopmental disorder
associated with severe epilepsy. We previously implicated GABAergic deficits onto layer (L) …

Angelman syndrome (AS) is a neurodevelopmental disorder caused by loss of the
maternally inherited allele of UBE3A. AS model mice, which carry a maternal Ube3a null …

Angelman syndrome (AS) is a neurodevelopmental disorder in which epilepsy is common (~
90%) and often refractory to antiepileptics. AS is caused by mutation of the maternal allele …

Angelman syndrome (AS) is a genetic neurodevelopmental disorder, most commonly
caused by deletion or mutation of the maternal allele of the UBE3A gene, with behavioral …

E3 ubiquitin ligase (UBE3A) levels in the brain need to be tightly regulated, as loss of
functional UBE3A protein is responsible for the severe neurodevelopmental disorder …

Angelman syndrome (AS) is a severe neurodevelopmental disorder that results from loss of
function of the maternal ubiquitin protein ligase E3A (UBE3A) allele. Due to neuron-specific …

Angelman syndrome (AS) is a severe neurodevelopmental disorder characterized by mental
retardation, seizures and sleep disturbances. It results from lack of the functional maternal …

Angelman syndrome (AS) is a debilitating neurodevelopmental disorder that is
characterized by motor dysfunction, intellectual disability, speech impairment, seizures and …

Background Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by
mutations affecting UBE3A gene expression. Previous studies in mice revealed distinct …

Angelman syndrome (AS) is a neurogenetic disorder caused by loss of maternal UBE3A
expression or mutation-induced dysfunction of its protein product, the E3 ubiquitin–protein …