We report the identification of multitarget anti-Alzheimer compounds designed by combining
a naphthoquinone function and a tacrine fragment. In vitro, 15 compounds displayed …

We discovered a small series of hit compounds that show multitargeting activities against
key targets in Alzheimer′ s disease (AD). The compounds were designed by combining the …

Alzheimer's disease (AD) is a progressive neurodegenerative disease that is characterized
by memory loss, cognitive impairment, and functional decline leading to dementia and …

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder. Several hallmarks
such as β-amyloid (Aβ) aggregation underlying amyloid plaque formation, Τ …

Multitarget therapeutic leads for Alzheimer's disease were designed on the models of
compounds capable of maintaining or restoring cell protein homeostasis and of inhibiting β …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder worldwide.
Currently, the only strategy for palliative treatment of AD is to inhibit acetylcholinesterase …

Alzheimer's disease (AD) is a genetically complex, progressive and irreversible
neurodegenerative disorder of the brain which involves multiple associated etiological …

Memoquin (1) is a lead compound multitargeted against Alzheimer's disease (AD). It is an
AChE inhibitor, free-radical scavenger, and inhibitor of amyloid-β (Aβ) aggregation. A new …

The multifactorial nature of Alzheimer's disease (AD) is a reason for the lack of effective
drugs as well as a basis for the development of “multi-target-directed ligands”(MTDLs). As …

Multitarget compounds are increasingly being pursued for the effective treatment of complex
diseases. Herein, we describe the design and synthesis of a novel class of shogaol–huprine …