Multitarget drug design strategy: quinone–tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effects
E Nepovimova, E Uliassi, J Korabecny… - Journal of medicinal …, 2014 - ACS Publications
We report the identification of multitarget anti-Alzheimer compounds designed by combining
a naphthoquinone function and a tacrine fragment. In vitro, 15 compounds displayed …
a naphthoquinone function and a tacrine fragment. In vitro, 15 compounds displayed …
Novel 8‐hydroxyquinoline derivatives as multitarget compounds for the treatment of Alzheimer′ s disease
F Prati, C Bergamini, R Fato, O Soukup… - …, 2016 - Wiley Online Library
We discovered a small series of hit compounds that show multitargeting activities against
key targets in Alzheimer′ s disease (AD). The compounds were designed by combining the …
key targets in Alzheimer′ s disease (AD). The compounds were designed by combining the …
Journey on naphthoquinone and anthraquinone derivatives: new insights in Alzheimer's disease
M Campora, V Francesconi, S Schenone, B Tasso… - Pharmaceuticals, 2021 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease that is characterized
by memory loss, cognitive impairment, and functional decline leading to dementia and …
by memory loss, cognitive impairment, and functional decline leading to dementia and …
Multitarget tacrine hybrids with neuroprotective properties to confront Alzheimer's disease
K Spilovska, J Korabecny… - Current Topics in …, 2017 - ingentaconnect.com
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder. Several hallmarks
such as β-amyloid (Aβ) aggregation underlying amyloid plaque formation, Τ …
such as β-amyloid (Aβ) aggregation underlying amyloid plaque formation, Τ …
Multitarget Therapeutic Leads for Alzheimer's Disease: Quinolizidinyl Derivatives of Bi‐and Tricyclic Systems as Dual Inhibitors of Cholinesterases and β‐Amyloid (Aβ) …
Multitarget therapeutic leads for Alzheimer's disease were designed on the models of
compounds capable of maintaining or restoring cell protein homeostasis and of inhibiting β …
compounds capable of maintaining or restoring cell protein homeostasis and of inhibiting β …
Novel triazole-quinoline derivatives as selective dual binding site acetylcholinesterase inhibitors
SP Mantoani, TPC Chierrito, AFL Vilela, CL Cardoso… - Molecules, 2016 - mdpi.com
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder worldwide.
Currently, the only strategy for palliative treatment of AD is to inhibit acetylcholinesterase …
Currently, the only strategy for palliative treatment of AD is to inhibit acetylcholinesterase …
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998–2018)
Alzheimer's disease (AD) is a genetically complex, progressive and irreversible
neurodegenerative disorder of the brain which involves multiple associated etiological …
neurodegenerative disorder of the brain which involves multiple associated etiological …
Multitargeted drugs discovery: balancing anti-amyloid and anticholinesterase capacity in a single chemical entity
Memoquin (1) is a lead compound multitargeted against Alzheimer's disease (AD). It is an
AChE inhibitor, free-radical scavenger, and inhibitor of amyloid-β (Aβ) aggregation. A new …
AChE inhibitor, free-radical scavenger, and inhibitor of amyloid-β (Aβ) aggregation. A new …
Sustainable drug discovery of multi-target-directed ligands for Alzheimer's disease
M Rossi, M Freschi… - Journal of medicinal …, 2021 - ACS Publications
The multifactorial nature of Alzheimer's disease (AD) is a reason for the lack of effective
drugs as well as a basis for the development of “multi-target-directed ligands”(MTDLs). As …
drugs as well as a basis for the development of “multi-target-directed ligands”(MTDLs). As …
Shogaol–huprine hybrids: dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties
FJ Pérez-Areales, O Di Pietro, A Espargaró… - Bioorganic & Medicinal …, 2014 - Elsevier
Multitarget compounds are increasingly being pursued for the effective treatment of complex
diseases. Herein, we describe the design and synthesis of a novel class of shogaol–huprine …
diseases. Herein, we describe the design and synthesis of a novel class of shogaol–huprine …
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