Peripheral mediators can contribute to the development and maintenance of inflammatory
and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two …

Disease and injury frequently result in pain and hyperalgesia. These abnormal sensory
events arise in part from the action of inflammatory mediators on the peripheral terminals of …

Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …

The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

Pain hypersensitivity after tissue injury and inflammation is contributed to by a reduction in
the threshold and an increase in the responsiveness of the peripheral terminals of high …

Nociception provides a means of neural feedback that allows the central nervous system
(CNS) to detect and avoid noxious and potentially damaging stimuli in both active and …

Arachidonic acid-derived prostaglandins not only contribute to the development of
inflammation as intercellular pro-inflammatory mediators, but also promote the excitability of …

Substance P (SP) is a prominent neuromodulator, which is produced and released by
peripheral damage-sensing (nociceptive) neurons; these neurons also express SP …

A decade ago the attention of pain scientists was focused on a small number of molecules
such as prostaglandin and bradykinin as peripheral pain mediators or modulators. These …

Pathological pain, consisting of tissue injury-induced inflammatory and nerve injury-induced
neuropathic pain, is an expression of neuronal plasticity. One component of this is that the …