Background Chronic limb-threatening ischaemia is the severest manifestation of peripheral
arterial disease and presents with ischaemic pain at rest or tissue loss (ulceration …

Objective To compare a'bypass-surgery-first'with a'balloon-angioplasty-first'revascularisation
strategy in patients with severe limb ischaemia (SLI) due to infrainguinal disease requiring …

Background Severe limb ischaemia is defined by ischaemic rest/night pain, tissue loss, or
both, secondary to arterial insufficiency and is increasingly caused by infra-popliteal (below …

The Bypass versus Angioplasty in Severe Ischemia of the Leg (BASIL) trial is the only
randomized controlled trial (RCT) to date comparing open surgical bypass with …

BACKGROUND: An intention-to-treat analysis of randomized Bypass versus Angioplasty in
Severe Ischaemia of the Leg (BASIL) trial data showed that initial randomization to a bypass …

Objectives: The most effective first-line treatment between endovascular therapy and bypass
surgery for patients with critical limb ischemia (CLI) is still not well defined. The primary aim …

BACKGROUND: An intention-to-treat analysis of the Bypass versus Angioplasty in Severe
Ischaemia of the Leg (BASIL) trial showed that in patients with severe lower limb ischemia …

Background Patients with chronic limb-threatening ischemia (CLTI) require revascularization
to improve limb perfusion and thereby limit the risk of amputation. It is uncertain whether an …

BACKGROUND: A 2005 interim analysis of the Bypass versus Angioplasty in Severe
Ischaemia of the Leg (BASIL) trial showed that in patients with severe lower limb ischemia …

Background Critical limb ischemia (CLI) is increasing in prevalence, and remains a
significant source of mortality and limb loss. The decision to recommend surgical or …