Evolution of organismal complexity and origin of novelties during vertebrate history has
been widely explored in context of both regulation of gene expression and gene duplication …

Background Understanding the genetic mechanisms underlying the organismal complexity
and origin of novelties during vertebrate history is one of the central goals of evolutionary …

Background The hypothesis that vertebrates have experienced two ancient, whole genome
duplications (WGDs) is of central interest to evolutionary biology and has been implicated in …

The widely popular hypothesis that there were two rounds of genome duplication by
polyploidization early in vertebrate history (the 2R hypothesis) has been difficult to test until …

Using a data set of protein translations associated with map positions in the human genome,
we identified 1520 mapped highly conserved gene families. By comparing sharing of …

Duplication of genes, giving rise to multigene families, has been a characteristic feature of
the evolution of eukaryotic genomes. In the case of vertebrates, it has been proposed that an …

The widely accepted notion that two whole‐genome duplications occurred during early
vertebrate evolution (the 2R hypothesis) stems from the fact that vertebrates often possess …

Background The vertebrate genome often contains closely spaced set of paralogous genes
from distinct gene families on typically two, three or four different chromosomes …

The hypothesis that the relatively large and complex vertebrate genome was created by two
ancient, whole genome duplications has been hotly debated, but remains unresolved. We …

BACKGROUND: Vertebrate genomes contain extensive intra-genomic conserved synteny,
which is the presence of similar set of genes on two or more chromosomes (paralogons) …