[HTML][HTML] Altered GABAergic signaling in brain disease at various stages of life

YS Kim, BE Yoon - Experimental neurobiology, 2017 - ncbi.nlm.nih.gov
In the healthy brain, gamma-aminobutyric acid (GABA) is regulated by neurons and glia.
This begs the question: what happens in the malfunctioning brain? There are many reasons …

Gamma-aminobutyric acid signaling in damage response, metabolism, and disease

K Kim, H Yoon - International Journal of Molecular Sciences, 2023 - mdpi.com
Gamma-aminobutyric acid (GABA) plays a crucial role in signal transduction and can
function as a neurotransmitter. Although many studies have been conducted on GABA in …

Γ-Aminobutyric acid in adult brain: an update

E Siucinska - Behavioural brain research, 2019 - Elsevier
This review assesses the parallel literature on the role of gamma-aminobutyric acid (GABA)
in brain plasticity and GABA elements dysfunction related disorders. I review historical and …

GABA receptors in brain development, function, and injury

C Wu, D Sun - Metabolic brain disease, 2015 - Springer
This review presents a brief overview of the γ-aminobutyric acid (GABA) system in the
developing and mature central nervous system (CNS) and its potential connections to …

The contribution of GABAergic dysfunction to neurodevelopmental disorders

K Ramamoorthi, Y Lin - Trends in molecular medicine, 2011 - cell.com
GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. The
GABAergic system is indispensable for maintaining the balance between excitation and …

Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives

G Deidda, IF Bozarth, L Cancedda - Frontiers in cellular neuroscience, 2014 - frontiersin.org
During mammalian ontogenesis, the neurotransmitter GABA is a fundamental regulator of
neuronal networks. In neuronal development, GABAergic signaling regulates neural …

The effect of age and sex on the expression of GABA signaling components in the human hippocampus and entorhinal cortex

J Ethiraj, TH Palpagama, C Turner, B van der Werf… - Scientific reports, 2021 - nature.com
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the nervous
system. The GABA signaling system in the brain is comprised of GABA synthesizing …

GABA as a rising gliotransmitter

BE Yoon, CJ Lee - Frontiers in neural circuits, 2014 - frontiersin.org
Gamma-amino butyric acid (GABA) is the major inhibitory neurotransmitter that is known to
be synthesized and released from GABAergic neurons in the brain. However, recent studies …

The long and winding road to gamma-amino-butyric acid as neurotransmitter

M Avoli, K Krnjević - Canadian Journal of Neurological Sciences, 2016 - cambridge.org
This review centers on the discoveries made during more than six decades of neuroscience
research on the role of gamma-amino-butyric acid (GABA) as neurotransmitter. In doing so …

Towards a better understanding of GABAergic remodeling in Alzheimer's disease

K Govindpani, B Calvo-Flores Guzmán… - International journal of …, 2017 - mdpi.com
γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the vertebrate brain.
In the past, there has been a major research drive focused on the dysfunction of the …