Etiology of the idiopathic childhood stroke remains unknown. In previous studies, the
immunologic process may be involved in the idiopathic stroke. Tumor necrosis factor—alpha …

BACKGROUND: Increasing evidences for the role of tumor necrosis factor-α (TNF-α) in the
occurrence of ischemic stroke (IS) have shown that it belongs to pro-inflammatory cytokines …

The role of genetic factors in the individual predisposition to develop ischemic stroke has
been assessed by previous studies performed both in animal models and in humans. The …

Background Tumor necrosis factor-α (TNF-α) is one of the most typical pro-inflammatory
cytokines with both beneficial and destructive properties for the central nervous system …

Aims: Two well-characterized polymorphisms in the tumor necrosis factor (TNF) gene, TNFα-
308G/A and TNFα-238G/A, are thought to play important roles in the etiology and …

Objective Numerous studies have investigated associations of gene polymorphisms and
circulating levels of TNF-α with ischemic stroke (IS), but the results were controversial. The …

Background Stroke is a common health problem; however, its pathogenesis is not clear.
Several studies have examined the association of− 308G> A promoter polymorphism in the …

INTRODUCTION: Introduction: Stroke is an important cause of mortality and morbidity in the
pediatric age group. There is increasing evidence on the role of proinflammatory cytokines …

We examined whether promoter region polymorphism in the tumor necrosis factor-α (TNFα)
gene at position− 308 affects the odds of cerebral infarction (CI). We genotyped 366 CI …

Tumor necrosis factor (TNF) is an important cytokine in the inflammation process of
atherosclerosis. Two biallelic polymorphisms in the TNF-α (TNF-α-308) and TNF-β (TNF-β+ …