Background: Persons with advanced cancer may participate in Phase 1 clinical trials–first-in-
human trials that are conducted with the main objectives of safety and dosing. The …

Background In cancer, phase 1 clinical trials on new drugs mostly involve patients with
advanced disease that is unresponsive to standard therapy. The purpose of this study was to …

Introduction: Advanced cancer patients participating in phase 1 clinical trials experience
considerable symptom burden. Palliative care (PC) may benefit these individuals by …

Objective This article identifies the core values that play a role in patients' decision-making
process about participation in early-phase clinical cancer trials. Methods Face-to-face, semi …

The purpose of this article is to describe the lessons learned in the course of a 5-year
research study on a palliative care intervention for persons on a Phase 1 clinical trial …

Background: ENABLE (Educate, Nurture, Advise Before Life Ends) II was one of the first
randomized controlled trials (RCTs) examining the effects of a concurrent oncology palliative …

Background: Palliative care (PC) is often misunderstood as exclusively pertaining to end-of-
life care, which may be consequential for its delivery. There is little research on how PC is …

Background: Intervention trials confirm that patients with advanced cancer receiving early
palliative care experience a better quality of life and show improved knowledge about and …

Background: Cancer patients with advanced disease who have exhausted most treatment
options are often offered participation in Phase I clinical trials. To date, studies that assess …

Objective: Several studies have reported the effectiveness of a variety of psychosocial
interventions in increasing levels of hope in palliative care patients. The experience of …