Achieving cancer-free surgical margins in oncologic surgery is critical to reduce the need for
additional adjuvant treatments and minimize tumor recurrence; however, there is a delicate …

Cancer is associated with specific cellular morphological changes, such as increased
nuclear size and crowding from rapidly proliferating cells. In situ tissue imaging using …

Objective: For tumor resections, margin status typically correlates with patient survival but
positive margin rates are generally high (up to 45% for head and neck cancer). Frozen …

Rapid assessment of prostate core biopsy pathology at the point-of-procedure could provide
benefit in a variety of clinical situations. Even with advanced transrectal ultrasound guidance …

Background Confocal laser endomicroscopy (CLE) is an optical device that aims to image
histological architecture and may be used to reduce positive surgical margins. The ability of …

Histopathologic examination of the pathologic specimens using hematoxylin & eosin stains
represents the backbone of the modern pathology. It is time-consuming; thus,“real-time” …

Background Robot-assisted radical prostatectomy (RARP) involves a tradeoff between
oncological control and functional outcomes. Intraoperative control of surgical margins …

We report the development of a structured illumination microscopy instrument specifically
designed for the requirements for high-area-throughput, optically-sectioned imaging of …

Identifying prostate cancer patients that are harboring aggressive forms of prostate cancer
remains a significant clinical challenge. Here we develop an approach based on …

The goal of oncologic surgeries is complete tumor resection, yet positive margins are
frequently found postoperatively using gold standard H&E-stained histology methods …