Although the existence of the limbal stem cell (LSC) niche is accepted, precise knowledge of
its three-dimensional (3D) architecture remains incomplete. The LSC niche was explored on …

Transparency of the human cornea is dependent upon the integrity of its epithelium and
hence a population of limbal epithelial stem cells (LESCs). We have previously shown that …

Background/aims: There is substantial evidence that mammalian epithelial stem cells are
located within well defined niches. Although the corneoscleral limbus is acknowledged as …

The limbal niche in the corneoscleral junction of the eye, habitat of the limbal epithelial stem
cells (LESC), facilitates corneal epithelial regeneration by providing physical support and …

Purpose: Creation of an in vitro model incorporating specific features that characterize a
particular stem niche would allow researchers to study stem cell behavior in a more …

Purpose: This study aims to clarify the existence of and to map the localization of different
proposed stem cell niches in the corneal limbal region. Materials and methods: One human …

Aim: In 2005 we reported the discovery of a novel anatomical structure at the limbus, which
we termed the limbal epithelial crypt (LEC). The purpose of this study was to further evaluate …

Limbal epithelial stem cells (LESCs) are essential to maintain the transparent ocular surface
required for vision. Despite great advances in our understanding of ocular stem cell biology …

Autologous cultivated limbal epithelial transplantation (CLET) is a successful therapy to
restore corneal epithelium when limbal epithelial stem cells are damaged unilaterally, which …

The limbal epithelial stem cell niche provides a unique, physically protective environment in
which limbal epithelial stem cells reside in close proximity with accessory cell types and their …