Aims Resistant hypertension is associated with a high risk of cardiovascular disease,
chronic kidney disease, and mortality. Yet, its management is challenging. This study aims to …

Objectives: This study sought to determine the current effectiveness and safety of
spironolactone for resistant hypertension. Methods: Pubmed, EMBASE and Cochrane …

Background The treatment of resistant hypertension (RH) is challenging. Several
observational studies have suggested that the addition of spironolactone to triple-drug …

In addition to the increasing prevalence of hypertension, the number of patients with
treatment-resistant hypertension is also rising. It is important to identify these patients in …

Q: How effective is spironolactone for treating resistant hypertension? EVIDENCE-BASED
ANSWER: VERY EFFECTIVE. Spironolactone reduces systolic blood pressure (SPB) by 11 …

Objective The efficacy of add-on use of spironolactone in patients with resistant
hypertension has been investigated in several small studies. We performed this meta …

The aim of this study is to compare spironolactone versus clonidine as the fourth drug in
patients with resistant hypertension in a multicenter, randomized trial. Medical therapy …

In addition to the increasing prevalence of hypertension, the number of patients with
treatment-resistant hypertension is also rising. It is important to identify these patients in …

Objective We conducted the first systematic review and meta-analysis to estimate the
specific prevalence of apparent treatment-resistant, pseudo-resistant and true-resistant …

Abstract We present Hypertension Canada's inaugural evidence-based recommendations
for the diagnosis and management of resistant hypertension. Hypertension is present in …