Caffeine causes most of its biological effects via antagonizing all types of adenosine
receptors (ARs): A1, A2A, A3, and A2B and, as does adenosine, exerts effects on neurons …

Alzheimer's disease (AD) is a neurodegenerative disorder of the central nervous system
manifested by cognitive and memory deterioration, a variety of neuropsychiatric symptoms …

Caffeine is the most consumed pychostimulant in the world, and it is known to affect basic
and fundamental human processes such as sleep, arousal, cognition and learning and …

Neurodegenerative disorders are some of the most feared illnesses in modern society, with
no effective treatments to slow or halt this neurodegeneration. Several decades after the …

Few studies to date have looked at the effects of caffeine on synaptic plasticity, and those
that did used very high concentrations of caffeine, whereas the brain concentrations attained …

Abstract Intracerebroventricular (icv) streptozotocin (STZ) administration induces
pathological and behavioral alterations similar to those observed in Alzheimer's disease …

Adenosine is a neuromodulator in the nervous system and it has recently been observed
that pharmacological blockade or gene disruption of adenosine A2A receptors confers …

Alzheimer's disease (AD) is the leading cause of dementia, predicted to be the most
significant health burden of the 21st century, with an estimated 131.5 million dementia …

Caffeine, the most widely consumed psychoactive drug, enhances attention/vigilance,
stabilizes mood, and might also independently enhance cognitive performance. Notably …

Consumption of caffeine, an adenosine receptor antagonist, was found to be inversely
associated with the incidence of Alzheimer's disease. Moreover, caffeine protects cultured …