Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization

J Zhao, X Li, J Hu, F Chen, S Qiao, X Sun… - Cardiovascular …, 2019 - academic.oup.com
Abstract Aims Mesenchymal stromal cells (MSCs) gradually become attractive candidates
for cardiac inflammation modulation, yet understanding of the mechanism remains elusive …

[HTML][HTML] Mesenchymal stem cell-derived exosomes regulate the polarization and inflammatory response of macrophages via miR-21-5p to promote repair after …

D Shen, Z He - Annals of translational medicine, 2021 - ncbi.nlm.nih.gov
Background Myocardial ischemia-reperfusion injury is a type of myocardial ischemia that
has a significant impact on patients' health. We aimed to explore the protective effect of …

Exosomes derived from pro‐inflammatory bone marrow‐derived mesenchymal stem cells reduce inflammation and myocardial injury via mediating macrophage …

R Xu, F Zhang, R Chai, W Zhou, M Hu… - Journal of cellular …, 2019 - Wiley Online Library
Exosomes are served as substitutes for stem cell therapy, playing important roles in
mediating heart repair during myocardial infarction injury. Evidence have indicated that …

Intravenous mesenchymal stem cell-derived exosomes ameliorate myocardial inflammation in the dilated cardiomyopathy

X Sun, A Shan, Z Wei, B Xu - Biochemical and Biophysical Research …, 2018 - Elsevier
Mesenchymal stem cells (MSCs) have been shown to be efficacy to attenuating
cardiovascular inflammation; however, there are many limitations to stem cell treatment …

[HTML][HTML] Mesenchymal stem cell-derived exosomes improve the microenvironment of infarcted myocardium contributing to angiogenesis and anti-inflammation

X Teng, L Chen, W Chen, J Yang, Z Yang… - Cellular Physiology and …, 2015 - karger.com
Background/Aims: Bone marrow mesenchymal stem cells (MSCs) widely applied for treating
myocardial infarction face survival challenges in the inflammatory and ischemia …

[HTML][HTML] IFN-γ enhances the efficacy of mesenchymal stromal cell-derived exosomes via miR-21 in myocardial infarction rats

J Zhang, Y Lu, Y Mao, Y Yu, T Wu, W Zhao… - Stem cell research & …, 2022 - Springer
Abstract Background Mesenchymal stromal cells (MSCs) activated with IFN-γ elicit stronger
physical effects. Exosomes (Exos) secreted from MSCs show protective effects against …

Transplantation of cardiac mesenchymal stem cell-derived exosomes promotes repair in ischemic myocardium

C Ju, Y Shen, G Ma, Y Liu, J Cai, I Kim… - Journal of …, 2018 - Springer
Our previous study demonstrated the beneficial effects of exosomes secreted by cardiac
mesenchymal stem cells (C-MSC-Exo) in protecting acute ischemic myocardium from …

[HTML][HTML] miRNA-181a over-expression in mesenchymal stem cell-derived exosomes influenced inflammatory response after myocardial ischemia-reperfusion injury

Z Wei, S Qiao, J Zhao, Y Liu, Q Li, Z Wei, Q Dai, L Kang… - Life sciences, 2019 - Elsevier
Aims The inflammation modulation effects of mesenchymal stromal cell-derived exosomes
(MSC-EXO) are well established. We aimed to explore the mechanism behind the …

[HTML][HTML] Exosomes derived from mesenchymal stem cells rescue myocardial ischaemia/reperfusion injury by inducing cardiomyocyte autophagy via AMPK and Akt …

L Liu, X Jin, CF Hu, R Li, Z Zhou… - Cellular physiology and …, 2017 - karger.com
Background/Aims: Reperfusion after an ischaemic insult might cause infarct extension.
Mesenchymal stem cell (MSC)-derived exosomes could attenuate myocardial remodelling in …

Exosomes from mesenchymal stem cells overexpressing MIF enhance myocardial repair

X Liu, X Li, W Zhu, Y Zhang, Y Hong… - Journal of cellular …, 2020 - Wiley Online Library
Accumulating evidence has shown that mesenchymal stem cell (MSC)‐derived exosomes
(exo) mediate cardiac repair following myocardial infarction (MI). Macrophage migration …