Women are born with a finite population of ovarian follicles, which are slowly depleted
during their reproductive years until reproductive failure (menopause) occurs. The rate of …

Premature ovarian failure (POF) is a cause of infertility that affects about 1% of women under
40, and is considered as idiopathic in 75% of cases. An occupational chemical origin has …

Introduction: Damage caused by xenobiotic compounds to the ovaries is a subject of
concern because of their critical role in reproduction. Female mammals are born with a finite …

Mammalian females are born with a finite number of nonrenewing primordial follicles, the
majority of which remain in a quiescent state for many years. Because of their nonrenewing …

Since the latter part of the twentieth century in this country, there has been an increase in the
number of working women and a tendency for women to postpone the start of a family …

Reproductive function in women can be compromised by exposure to toxic chemicals. ¹
Recently many couples have postponed the start of a family because of the women pursuing …

Endocrine-disrupting chemicals (EDCs) are found abundantly in the environment, resulting
in daily human exposure. This is of concern because many EDCs are known to target the …

How chemotherapy affects dormant ovarian primordial follicles is unclear. The
'burnout'theory, studied only in mice, suggests cyclophosphamide enhances primordial …

Ovarian dysfunction induced by 2-bromopropane (2-BP) has been described in female
factory workers and experimental animals. However, the underlying mechanism is still …

BACKGROUND The occupational chemical 4‐vinylcyclohexene (VCH) has been shown to
cause destruction of small pre‐antral follicles in ovaries of mice. Further, its monoepoxide …