[HTML][HTML] Burden of rare variants in synaptic genes in patients with severe tinnitus: An exome based extreme phenotype study
Background tinnitus is a heterogeneous condition associated with audiological and/or
mental disorders. Chronic, severe tinnitus is reported in 1% of the population and it shows a …
mental disorders. Chronic, severe tinnitus is reported in 1% of the population and it shows a …
Using coding and non-coding rare variants to target candidate genes in patients with severe tinnitus
A Gallego-Martinez, A Escalera-Balsera… - npj Genomic …, 2022 - nature.com
Tinnitus is the phantom percept of an internal non-verbal set of noises and tones. It is
reported by 15% of the population and it is usually associated with hearing and/or brain …
reported by 15% of the population and it is usually associated with hearing and/or brain …
Rare deletions or large duplications contribute to genetic variation in patients with severe tinnitus and Meniere disease
A Escalera-Balsera, AM Parra-Perez… - Genes, 2023 - mdpi.com
Meniere disease (MD) is a debilitating disorder of the inner ear defined by sensorineural
hearing loss (SNHL) associated with episodes of vertigo and tinnitus. Severe tinnitus, which …
hearing loss (SNHL) associated with episodes of vertigo and tinnitus. Severe tinnitus, which …
Genetics of tinnitus: an emerging area for molecular diagnosis and drug development
Subjective tinnitus is the perception of sound in the absence of external or bodily-generated
sounds. Chronic tinnitus is a highly prevalent condition affecting over 70 million people in …
sounds. Chronic tinnitus is a highly prevalent condition affecting over 70 million people in …
Genetic predisposition to tinnitus in the UK Biobank population
ME Urbanek, J Zuo - Scientific reports, 2021 - nature.com
Tinnitus, the phantom perception of noise originating from the inner ear, has been reported
by 15% of the world's population, with many patients reporting major deficits to cognition and …
by 15% of the world's population, with many patients reporting major deficits to cognition and …
A genome-wide association study of tinnitus reveals shared genetic links to neuropsychiatric disorders
Tinnitus, a phantom perception of sound in the absence of any external sound source, is a
prevalent health condition often accompanied by psychiatric comorbidities. Recent genome …
prevalent health condition often accompanied by psychiatric comorbidities. Recent genome …
A pilot genome-wide association study identifies potential metabolic pathways involved in tinnitus
A Gilles, G Van Camp, P Van de Heyning… - Frontiers in …, 2017 - frontiersin.org
Tinnitus, the perception of an auditory phantom sound in the form of ringing, buzzing,
roaring, or hissing in the absence of an external sound source, is perceived by~ 15% of the …
roaring, or hissing in the absence of an external sound source, is perceived by~ 15% of the …
A systematic review of extreme phenotype strategies to search for rare variants in genetic studies of complex disorders
Exome sequencing has been commonly used to characterize rare diseases by selecting
multiplex families or singletons with an extreme phenotype (EP) and searching for rare …
multiplex families or singletons with an extreme phenotype (EP) and searching for rare …
A Systematic Review on the Genetic Contribution to Tinnitus
P Perez-Carpena, JA Lopez-Escamez… - Journal of the …, 2024 - Springer
Purpose To assess the available evidence to support a genetic contribution and define the
role of common and rare variants in tinnitus. Methods After a systematic search and quality …
role of common and rare variants in tinnitus. Methods After a systematic search and quality …
Genetics of tinnitus: still in its infancy
B Vona, I Nanda, W Shehata-Dieler… - Frontiers in neuroscience, 2017 - frontiersin.org
Tinnitus is the perception of a phantom sound that affects between 10 and 15% of the
general population. Despite this considerable prevalence, treatments for tinnitus are …
general population. Despite this considerable prevalence, treatments for tinnitus are …