Genome damage and their defective repair have been etiologically linked to degenerating
neurons in many subtypes of amyotrophic lateral sclerosis (ALS) patients; however, the …

Background Pathological forms of TAR DNA-binding protein 43 (TDP-43) are present in
motor neurons of almost all amyotrophic lateral sclerosis (ALS) patients, and mutations in …

Amyotrophic lateral sclerosis (ALS), a common motor neuron disease affecting two per
100,000 people worldwide, encompasses at least five distinct pathological subtypes …

Mutations in TDP-43, a DNA/RNA-binding protein, cause an inherited form of the
neurodegenerative disease amyotrophic lateral sclerosis (ALS). Two recent studies …

TDP-43 is a DNA and RNA binding protein involved in RNA processing and with structural
resemblance to heterogeneous ribonucleoproteins (hnRNPs), whose depletion sensitizes …

Dominant mutations in the RNA/DNA-binding protein TDP-43 have been linked to
amyotrophic lateral sclerosis (ALS). Here, we screened genomic DNA extracted from spinal …

Dominant mutations in two DNA/RNA binding proteins, TDP-43 and FUS/TLS, are causes of
inherited Amyotrophic Lateral Sclerosis (ALS). TDP-43 and FUS/TLS have striking structural …

Emerging studies reveal that neurodegenerative disorders, including amyotrophic lateral
sclerosis (ALS) and frontotemporal dementia (FTD), are commonly linked to DNA damage …

Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease that causes motor neuron
degeneration, progressive motor dysfunction, paralysis, and death. Although multiple …

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are
characterized by cytoplasmic protein aggregates in the brain and spinal cord that include …