Glial GABA, synthesized by monoamine oxidase B, mediates tonic inhibition
Key points Here we show that glial gamma aminobutyric acid (GABA) is produced by
monoamine oxidase B (MAOB), utilizing a polyamine, putrescine. The concentration of …
monoamine oxidase B (MAOB), utilizing a polyamine, putrescine. The concentration of …
Control of motor coordination by astrocytic tonic GABA release through modulation of excitation/inhibition balance in cerebellum
J Woo, JO Min, DS Kang, YS Kim… - Proceedings of the …, 2018 - National Acad Sciences
Tonic inhibition in the brain is mediated through an activation of extrasynaptic GABAA
receptors by the tonically released GABA, resulting in a persistent GABAergic inhibitory …
receptors by the tonically released GABA, resulting in a persistent GABAergic inhibitory …
GABA, a forgotten gliotransmitter
MC Angulo, K Le Meur, AS Kozlov, S Charpak… - Progress in …, 2008 - Elsevier
The amino acid γ-aminobutiric acid (GABA) is a major inhibitory transmitter in the vertebrate
central nervous system (CNS) where it can be released by neurons and by glial cells …
central nervous system (CNS) where it can be released by neurons and by glial cells …
Astrocytes regulate inhibitory neurotransmission through GABA uptake, metabolism, and recycling
JV Andersen, A Schousboe… - Essays in …, 2023 - portlandpress.com
Synaptic regulation of the primary inhibitory neurotransmitter γ-aminobutyric acid (GABA) is
essential for brain function. Cerebral GABA homeostasis is tightly regulated through multiple …
essential for brain function. Cerebral GABA homeostasis is tightly regulated through multiple …
The GABA paradox: multiple roles as metabolite, neurotransmitter, and neurodifferentiative agent
HS Waagepetersen, U Sonnewald… - Journal of …, 1999 - Wiley Online Library
GABA, which is present in the brain in large amounts, is distributed among distinctly different
cellular pools, possibly reflecting its multiple functions as metabolite, neurotransmitter, and …
cellular pools, possibly reflecting its multiple functions as metabolite, neurotransmitter, and …
[HTML][HTML] The amount of astrocytic GABA positively correlates with the degree of tonic inhibition in hippocampal CA1 and cerebellum
A tonic form of synaptic inhibition occurs in discrete regions of the central nervous system
and has an important role in controlling neuronal excitability. Recently, we reported that …
and has an important role in controlling neuronal excitability. Recently, we reported that …
Gamma-aminobutyric acid (GABA) metabolism in mammalian neural and nonneural tissues
NJK Tillakaratne, L Medina-Kauwe… - … and Physiology Part A …, 1995 - Elsevier
4-Aminobutyric acid (GABA), a major inhibitory neurotransmitter of mammalian central
nervous system, is found in a wide range of organisms, from prokaryotes to vertebrates …
nervous system, is found in a wide range of organisms, from prokaryotes to vertebrates …
GAD65 is essential for synthesis of GABA destined for tonic inhibition regulating epileptiform activity
AB Walls, LH Nilsen, EM Eyjolfsson… - Journal of …, 2010 - Wiley Online Library
J. Neurochem.(2010) 115, 1398–1408. Abstract GABA is synthesized from glutamate by
glutamate decarboxylase (GAD), which exists in two isoforms, that is, GAD65 and GAD67. In …
glutamate decarboxylase (GAD), which exists in two isoforms, that is, GAD65 and GAD67. In …
GABA tone regulation and its cognitive functions in the brain
Abstract γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter released at
GABAergic synapses, mediating fast-acting phasic inhibition. Emerging lines of evidence …
GABAergic synapses, mediating fast-acting phasic inhibition. Emerging lines of evidence …
[HTML][HTML] GABA as a rising gliotransmitter
Gamma-amino butyric acid (GABA) is the major inhibitory neurotransmitter that is known to
be synthesized and released from GABAergic neurons in the brain. However, recent studies …
be synthesized and released from GABAergic neurons in the brain. However, recent studies …