Short-chain free-fatty acid G protein-coupled receptors in colon cancer

NH Moniri, Q Farah - Biochemical Pharmacology, 2021 - Elsevier
The dietary role of macronutrients and their metabolites in cancer has been evident for many
decades. Dietary ingestion of fat, carbohydrates, protein, and fiber, as well as probiotics that …

[HTML][HTML] Participation of short-chain fatty acids and their receptors in gut inflammation and colon cancer

MD Carretta, J Quiroga, R López, MA Hidalgo… - Frontiers in …, 2021 - frontiersin.org
Short-chain fatty acids (SCFAs) are the main metabolites produced by the bacterial
fermentation of dietary fiber, and they play a critical role in the maintenance of intestinal …

The role of diet related short-chain fatty acids in colorectal cancer metabolism and survival: prevention and therapeutic implications

SD Gomes, CS Oliveira, J Azevedo-Silva… - Current medicinal …, 2020 - ingentaconnect.com
Colorectal Cancer (CRC) is a major cause of cancer-related death worldwide. CRC
increased risk has been associated with alterations in the intestinal microbiota, with …

Benefits of short-chain fatty acids and their receptors in inflammation and carcinogenesis

S Sivaprakasam, PD Prasad, N Singh - Pharmacology & therapeutics, 2016 - Elsevier
Epidemiological studies have linked increased incidence of inflammatory diseases and
intestinal cancers in the developed parts of the world to the consumption of diets poor in …

Gut microbiota-derived short-chain fatty acids and colorectal cancer: Ready for clinical translation?

H Hou, D Chen, K Zhang, W Zhang, T Liu, S Wang… - Cancer Letters, 2022 - Elsevier
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer-related death worldwide. It involves the complex interactions between genetic …

Free fatty acid receptors and cancer: from nutrition to pharmacology

MM Hopkins, KE Meier - Free Fatty Acid Receptors, 2017 - Springer
The effects of fatty acids on cancer cells have been studied for decades. The roles of dietary
long-chain n-3 polyunsaturated fatty acids, and of microbiome-generated short-chain butyric …

Oncogenic signaling of the free-fatty acid receptors FFA1 and FFA4 in human breast carcinoma cells

PF Karmokar, NH Moniri - Biochemical pharmacology, 2022 - Elsevier
Globally, breast cancer is the most frequent type of cancer in women, and most breast
cancer-associated deaths are due to metastasis and recurrence of the disease. Dietary …

G‐protein‐coupled receptor for short‐chain fatty acids suppresses colon cancer

Y Tang, Y Chen, H Jiang… - International journal of …, 2011 - Wiley Online Library
GPR43 is a G‐protein‐coupled receptor for short‐chain fatty acids (SCFAs). Expression of
GPR43 is detected in hematopoietic tissues and the large intestine. SCFAs are derived from …

[HTML][HTML] Short chain fatty acids and colon cancer

LH Augenlicht, JM Mariadason, A Wilson, D Arango… - The Journal of …, 2002 - Elsevier
The development of intestinal cancer involves complex genetic and epigenetic alterations in
the intestinal mucosa. The principal signaling pathway responsible for the initiation of tumor …

[HTML][HTML] Short-chain fatty acids in cancer pathogenesis

MA Feitelson, A Arzumanyan, A Medhat… - Cancer and Metastasis …, 2023 - Springer
Cancer is a multi-step process that can be viewed as a cellular and immunological shift
away from homeostasis in response to selected infectious agents, mutations, diet, and …