Implication of lncRNA MSTRG. 81401 in Hippocampal Pyroptosis Induced by P2X7 Receptor in Type 2 Diabetic Rats with Neuropathic Pain Combined with …

T Zhan, S Tang, J Du, J Liu, B Yu, Y Yang… - International Journal of …, 2024 - mdpi.com
Major depressive disorder (MDD) is a common complication of diabetes and is often
observed alongside diabetic neuropathic pain (DNP) as a comorbidity in diabetic patients …

Long non-coding RNA MSTRG. 81401 short hairpin RNA relieves diabetic neuropathic pain and behaviors of depression by inhibiting P2X4 receptor expression in …

M Sun, M Zhang, H Yin, H Tu, Y Wen, X Wei… - Purinergic …, 2022 - Springer
Patients with diabetic neuropathic pain (DNP) experience immense physical and mental
suffering, which is comorbid with other mental disorders, including major depressive …

Effects of LncRNA BC168687 siRNA on Diabetic Neuropathic Pain Mediated by P2X7 Receptor on SGCs in DRG of Rats

C Liu, J Tao, H Wu, Y Yang, Q Chen… - BioMed research …, 2017 - Wiley Online Library
Diabetic neuropathic pain (DNP), one of the early symptoms of diabetic neuropathy, relates
to metabolic disorders induced by high blood glucose, neurotrophic vascular ischemia and …

LncRNA NONRATT021972 siRNA regulates neuropathic pain behaviors in type 2 diabetic rats through the P2X7 receptor in dorsal root ganglia

S Liu, L Zou, J Xie, W Xie, S Wen, Q Xie, Y Gao, G Li… - Molecular brain, 2016 - Springer
Background Long non-protein-coding RNAs (lncRNAs) are involved in the pathological
processes of nervous system diseases. NONRATT021972 is an lncRNA. This study explores …

LncRNA uc.48+ is involved in diabetic neuropathic pain mediated by the P2X3 receptor in the dorsal root ganglia

S Wang, H Xu, L Zou, J Xie, H Wu, B Wu, Z Yi, Q Lv… - Purinergic …, 2016 - Springer
Some long non-coding RNAs (lncRNAs) participate in physiological processes that maintain
cellular and tissue homeostasis, and thus, the dysregulated expression of lncRNAs is …

lncRNA NONRATT021972 siRNA Decreases Diabetic Neuropathic Pain Mediated by the P2X3 Receptor in Dorsal Root Ganglia

H Peng, L Zou, J Xie, H Wu, B Wu, G Zhu, Q Lv… - Molecular …, 2017 - Springer
Long noncoding RNAs (lncRNAs) participate in physiological and pathophysiological
processes. Type 2 diabetes mellitus (T2DM) accounts for more than 90% of all cases of …

Beneficial effects of lncRNA-UC. 360+ shRNA on diabetic cardiac sympathetic damage via NLRP3 inflammasome-induced pyroptosis in stellate ganglion

L Shi, Q Hu, L Li, R Yang, X Xu, J Du, L Zou, G Li… - ACS …, 2022 - ACS Publications
Hyperglycemia is one of the common symptoms of diabetes, and it produces excessive
reactive oxygen species (ROS). This study investigated whether the long noncoding RNA …

LncRNA-UC.25 + shRNA Alleviates P2Y14 Receptor–Mediated Diabetic Neuropathic Pain via STAT1

B Wu, C Zhou, Z Xiao, G Tang, H Guo, Z Hu, Q Hu… - Molecular …, 2022 - Springer
Diabetic neuropathic pain (DNP) is a common complication of diabetes, and its complicated
pathogenesis, as well as clinical manifestations, has brought great trouble to clinical …

NLRP3 inflammasome-dependent pyroptosis and apoptosis in hippocampus neurons mediates depressive-like behavior in diabetic mice

DX Li, CN Wang, Y Wang, CL Ye, L Jiang… - Behavioural brain …, 2020 - Elsevier
A relatively large number of diabetic patients risk complications of clinical depression that
lead to poorer quality of life, however the precise mechanisms for diabetes-associated …

Silencing P2X7R alleviates diabetic neuropathic pain involving TRPV1 via PKCε/P38MAPK/NF-κB signaling pathway in rats

L Chen, H Wang, J Xing, X Shi, H Huang… - International Journal of …, 2022 - mdpi.com
Transient receptor potential vanillic acid 1 (TRPV1) is an ion channel activated by heat and
inflammatory factors involved in the development of various types of pain. The P2X7 …