Functional connectivity changes resemble patterns of pTDP-43 pathology in amyotrophic lateral sclerosis

I Schulthess, M Gorges, HP Müller, D Lulé… - Scientific reports, 2016 - nature.com
Abstract 'Resting-state'fMRI allows investigation of alterations in functional brain
organization that are associated with an underlying pathological process. We determine …

Correlation between structural and functional connectivity impairment in amyotrophic lateral sclerosis

R Schmidt, E Verstraete, MA de Reus… - Human brain …, 2014 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, characterized by
progressive loss of motor function. While the pathogenesis of ALS remains largely unknown …

Brain connectivity and network analysis in amyotrophic lateral sclerosis

V Renga - Neurology Research International, 2022 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no effective
treatment or cure. ALS is characterized by the death of lower motor neurons (LMNs) in the …

Changes of resting state brain networks in amyotrophic lateral sclerosis

B Mohammadi, K Kollewe, A Samii, K Krampfl… - Experimental …, 2009 - Elsevier
The defining feature of amyotrophic lateral sclerosis is degeneration of upper and lower
motor neurons but extramotor involvement, evidenced for example by executive dysfunction …

Patterned functional network disruption in amyotrophic lateral sclerosis

S Dukic, R McMackin, T Buxo, A Fasano… - Human Brain …, 2019 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease primarily
affecting motor function, with additional evidence of extensive nonmotor involvement …

Brain functional connectome abnormalities in amyotrophic lateral sclerosis are associated with disability and cortical hyperexcitability

N Geevasinga, MS Korgaonkar… - European journal of …, 2017 - Wiley Online Library
Background and purpose The present study utilized a multimodal approach encompassing
connectome networks combined with brain volume analysis, and assessment of cortical …

Structural brain network imaging shows expanding disconnection of the motor system in amyotrophic lateral sclerosis

E Verstraete, JH Veldink, LH van den Berg… - Human brain …, 2014 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease, which primarily
targets the motor system. The structural integrity of the motor network and the way it is …

Abnormal functional connectivity density in amyotrophic lateral sclerosis

W Li, J Zhang, C Zhou, W Hou, J Hu, H Feng… - Frontiers in Aging …, 2018 - frontiersin.org
Purpose: Amyotrophic lateral sclerosis (ALS) is a motor neuro-degenerative disorder that
also damages extra-motor neural pathways. A significant proportion of existing evidence …

Motor network degeneration in amyotrophic lateral sclerosis: a structural and functional connectivity study

E Verstraete, MP Van Den Heuvel, JH Veldink… - PloS one, 2010 - journals.plos.org
Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease
characterised by motor neuron degeneration. How this disease affects the central motor …

EEG functional network topology is associated with disability in patients with amyotrophic lateral sclerosis

M Fraschini, M Demuru, A Hillebrand, L Cuccu… - Scientific reports, 2016 - nature.com
Abstract Amyotrophic Lateral Sclerosis (ALS) is one of the most severe neurodegenerative
diseases, which is known to affect upper and lower motor neurons. In contrast to the …