[HTML][HTML] Cardiac electrophysiology in mice: a matter of size

S Kaese, S Verheule - Frontiers in physiology, 2012 - frontiersin.org
Over the last decade, mouse models have become a popular instrument for studying cardiac
arrhythmias. This review assesses in which respects a mouse heart is a miniature human …

Cardiac arrhythmias: from (transgenic) mice to men

B London - Journal of cardiovascular electrophysiology, 2001 - Wiley Online Library
Cardiac Arrhythmias. Transgenic and gene‐targeted mice now are frequently used to study
cardiac arrhythmias due to the ease with which the mouse genome can be manipulated …

Studying cardiac arrhythmias in the mouse—a reasonable model for probing mechanisms?

JM Nerbonne - Trends in cardiovascular medicine, 2004 - Elsevier
The normal mechanical functioning of the heart depends on proper electrical functioning,
reflected in the sequential activation of pacemaker cells, and the normal propagation of …

[HTML][HTML] Ventricular arrhythmogenesis: insights from murine models

IN Sabir, MJ Killeen, AA Grace, CLH Huang - Progress in biophysics and …, 2008 - Elsevier
Ventricular arrhythmias are the key underlying cause of sudden cardiac death, a common
cause of mortality and a significant public health burden. Insights into the …

In vivo cardiac electrophysiology studies in the mouse

CI Berul, MJ Aronovitz, PJ Wang, ME Mendelsohn - Circulation, 1996 - Am Heart Assoc
Background This report describes a novel in vivo mouse epicardial cardiac
electrophysiology study based on clinical protocols used to evaluate cardiac conduction in …

Animal models of arrhythmia: classic electrophysiology to genetically modified large animals

S Clauss, C Bleyer, D Schuettler, P Tomsits… - Nature Reviews …, 2019 - nature.com
Arrhythmias are common and contribute substantially to cardiovascular morbidity and
mortality. The underlying pathophysiology of arrhythmias is complex and remains …

Mouse electrocardiography: an interval of thirty years

XHT Wehrens, S Kirchhoff… - Cardiovascular …, 2000 - academic.oup.com
The interest in mouse electrophysiology is expanding fast, despite the marked differences
between mouse and man. Different methods have become available to analyse the …

ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology …

KE Odening, AM Gomez, D Dobrev, L Fabritz… - EP …, 2021 - academic.oup.com
Cardiac arrhythmias are a major cause of death and disability. A large number of
experimental cell and animal models have been developed to study arrhythmogenic …

Animal models to study cardiac arrhythmias

DJ Blackwell, J Schmeckpeper… - Circulation research, 2022 - Am Heart Assoc
Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide, accounting
for 10% to 15% of all deaths. Although most arrhythmias are due to acquired heart disease …

Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals

CM Ripplinger, AV Glukhov, MW Kay… - American Journal …, 2022 - journals.physiology.org
Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although
recent advances in cell-based models, including human-induced pluripotent stem cell …