Approximately 30% of colorectal carcinomas develop via a serrated neoplasia pathway,
named for the pattern of crypts in the precursor polyps. Molecular abnormalities consistently …

The serrated pathway (SP) can be viewed as two parallel, but partially overlapping, arrays of
colorectal precursor lesions, and their respective endpoint carcinomas, that are distinct from …

Colorectal cancer (CRC) ranks among the three most common cancers in terms of both
cancer incidence and cancer‐related deaths in most Western countries. Serrated …

Approximately 30% of colorectal carcinomas develop via the serrated neoplasia pathway
characterized by widespread DNA methylation and frequent BRAF mutation. Serrated …

Serrated adenocarcinoma is a recently described subset of colorectal cancer (CRC), which
account for about 10% of all CRCs and follows an alternative pathway in which serrated …

Colorectal cancer (CRC) is a leading cause of cancer death worldwide. It includes different
subtypes that differ in their clinical and prognostic features. In the past decade, in addition to …

Although recognized 25 years ago, the traditional serrated adenoma (TSA) remains an
ongoing source of diagnostic and biologic debate. Recent research has greatly improved …

Studies of colorectal cancer (CRC) originating through the conventional adenoma-
carcinoma sequence have provided insight into the molecular mechanisms controlling its …

Adenocarcinoma of the large intestine can no longer be considered one disease but rather a
family of diseases with different precursor lesions, different molecular pathways, and …

The aim of this study was to compare BRAF and KRAS, CpG island methylator phenotype
(CIMP), and microsatellite instability (MSI) status in each of the histologic categories …