The mechanisms responsible for helicase loading during the initiation of chromosome
replication in bacteria are unclear. Here we report both a positive and a negative …

Bidirectional DNA replication from a chromosome origin requires the asymmetric loading of
two helicases, one for each replisome. Our understanding of the molecular mechanisms …

DNA replication is a fundamental biological process that is tightly regulated in all living cells.
In bacteria, the master regulator DnaA controls when and where replication begins by …

Genome replication is a fundamental biological activity shared by all organisms.
Chromosomal replication proceeds bidirectionally from origins, requiring the loading of two …

DNA replication is a fundamental biological process that is tightly regulated in all cells. In
bacteria, DnaA controls when and where replication begins by building a step‐wise complex …

Initiation of DNA replication is required for cell viability and passage of genetic information to
the next generation. Studies in Escherichia coli and Bacillus subtilis have established A …

Delivery of the replicative helicase onto DNA is an essential step in the initiation of
replication. In bacteria, DnaC (in Escherichia coli) and DnaI (in Bacillus subtilis) are …

The replicative DNA helicase translocates on single-stranded DNA to drive replication forks
during chromosome replication. In most bacteria the ubiquitous replicative helicase, DnaB …

Genome replication is a fundamental requirement for the proliferation of all cells. Throughout
the domains of life, conserved DNA replication initiation proteins assemble at specific …

In bacteria, transcription and DNA replication occur concurrently, inevitably causing
replication‐transcription conflicts. Conflicts can occur both co‐directionally (leading strand …