Antibody and T‐cell receptors (TCRs) are the primary recognition molecules of the adaptive
immune system. Antibodies have been extensively characterized and are being developed …

The use of T cell receptors (TCRs) as potential therapeutic agents provides an opportunity to
target a greatly expanded array of antigens, compared to those now targeted with …

Here we have constructed a single-chain T-cell receptor (scTCR) scaffold with high stability
and soluble expression efficiency by directed evolution and yeast surface display. We …

The T cell receptor (TCR) determines the cellular response to antigens, which are presented
on the surface of target cells in the form of a peptide bound to a product of the major …

A strategy for the production of small, soluble, single-chain T-cell receptor (scTCR)
fragments that carry an intact TCR antigen-combining site is presented. The rationale is …

T-cell receptors (TCRs) are membrane anchored heterodimers structurally related to
antibody molecules. Single-chain antibodies can be engineered by linking the two variable …

The antigen receptors made by lympho-cytes are antibodies, which exist as soluble and cell-
bound molecules, and T cell receptors (TCRs), which are always found on cell surfaces. The …

We have produced a chimeric single‐chain T cell receptor (TcR) that combines the specific
antibody recognition function and TcR/CD3 signaling properties within the same polypeptide …

The use of recombinant T cell receptors (TCRs) to target therapeutic interventions has been
hindered by the naturally low affinity of TCR interactions with peptide major …

The heterodimeric αβ T cell receptor (TCR) for antigen is the key determinant of T cell
specificity. The structure of the TCR is very similar to that of antibodies, but the engineering …