T cell activation requires extracellular stimulatory signals that are mainly mediated by T cell
receptor (TCR) complexes. The TCR recognizes antigens on major histocompatibility …

CD4+ T cells are critical components of the adaptive immune system. The T cell receptor
(TCR) and co-receptor signaling cascades shape the phenotype and functions of CD4+ T …

The remarkable T cell receptor (TCR) performs essential functions in the initiation of
intracellular signals required for T cell development, repertoire selection and effector …

T cell development, differentiation, and maintenance are orchestrated by 2 key signaling
axes: the antigen-specific TCR and cytokine-mediated signals. The TCR signals the …

The adaptive phase of the immune response begins with engagement on CD4+ helper T
cells of the T cell antigen receptor (TCR) 1 by its ligand, a small foreign peptide bound to a …

T cell receptors (TCRs) are protein complexes formed by six different polypeptides. In most T
cells, TCRs are composed of αβ subunits displaying immunoglobulin-like variable domains …

The T cell receptor (TCR) recognizes self or foreign antigens presented by major
histocompatibility complex (MHC) molecules. Engagement of the TCR triggers the formation …

When T cells encounter antigens via the T cell antigen receptor (TCR), information about the
quantity and quality of antigen engagement is relayed to the intracellular signal transduction …

The series of events leading to T‐cell activation following antigen recognition has been
extensively investigated. Although the exact mechanisms of ligand binding and transmission …

The initiation of T cell antigen receptor signaling is a key step that can result in T cell
activation and the orchestration of an adaptive immune response. Early events in T cell …