Efforts to model the human gut microbiome in mice have led to important insights into the
mechanisms of host-microbe interactions. However, the model communities studied to date …

Human microbiota-associated (HMA) mice have been used extensively in gut microbiome
research. Here we discuss ecological and evolutionary aspects of the mammalian-gut …

Human health and disease have increasingly been shown to be impacted by the gut
microbiota, and mouse models are essential for investigating these effects. However, the …

Laboratory mice, while paramount for understanding basic biological phenomena, are
limited in modeling complex diseases of humans and other free-living mammals. Because …

Intestinal bacteria influence mammalian physiology, but many types of bacteria are still
uncharacterized. Moreover, reference strains of mouse gut bacteria are not easily available …

The important and diverse roles of the gut microbiota in human health and disease are
increasingly recognized. The difficulty of inferring causation from metagenomic microbiome …

Background Inappropriate cross talk between mammals and their gut microbiota may trigger
intestinal inflammation and drive extra-intestinal immune-mediated diseases. Epithelial cells …

Laboratory mice are the most commonly used animal model in translational medical
research. In recent years, the impact of the gut microbiota (ie communities of …

The gut microbiota influences host responses at practically every level, and as research into
host-microbe interactions expands, it is not surprising that we are uncovering similar roles …

The proportion of the human gut bacterial community that is recalcitrant to culture remains
poorly defined. In this report, we combine high-throughput anaerobic culturing techniques …