The thalamus in psychosis spectrum disorder
A Anticevic, MM Halassa - Frontiers in Neuroscience, 2023 - frontiersin.org
Psychosis spectrum disorder (PSD) affects 1% of the world population and results in a
lifetime of chronic disability, causing devastating personal and economic consequences …
lifetime of chronic disability, causing devastating personal and economic consequences …
[HTML][HTML] Circuit-based approaches to understanding corticostriatothalamic dysfunction across the psychosis continuum
Dopamine is known to play a role in the pathogenesis of psychotic symptoms, but the
mechanisms driving dopaminergic dysfunction in psychosis remain unclear. Considerable …
mechanisms driving dopaminergic dysfunction in psychosis remain unclear. Considerable …
[HTML][HTML] Thalamic connectivity system across psychiatric disorders: current status and clinical implications
The thalamic connectivity system, with the thalamus as the central node, enables
transmission of the brain's neural computations via extensive connections to cortical …
transmission of the brain's neural computations via extensive connections to cortical …
Bridging the gap? Altered thalamocortical connectivity in psychotic and psychedelic states
Psychiatry has a well-established tradition of comparing drug-induced experiences to
psychotic symptoms, based on shared phenomena such as altered perceptions. The present …
psychotic symptoms, based on shared phenomena such as altered perceptions. The present …
Characterizing thalamo-cortical disturbances in schizophrenia and bipolar illness
Schizophrenia is a devastating neuropsychiatric syndrome associated with distributed brain
dysconnectivity that may involve large-scale thalamo-cortical systems. Incomplete …
dysconnectivity that may involve large-scale thalamo-cortical systems. Incomplete …
The associative thalamus: a switchboard for cortical operations and a promising target for schizophrenia
A Mukherjee, MM Halassa - The Neuroscientist, 2024 - journals.sagepub.com
Schizophrenia is a brain disorder that profoundly perturbs cognitive processing. Despite the
success in treating many of its symptoms, the field lacks effective methods to measure and …
success in treating many of its symptoms, the field lacks effective methods to measure and …
Neuroimaging as a window into the pathophysiological mechanisms of schizophrenia
NV Kraguljac, AC Lahti - Frontiers in psychiatry, 2021 - frontiersin.org
Schizophrenia is a complex neuropsychiatric disorder with a diverse clinical phenotype that
has a substantial personal and public health burden. To advance the mechanistic …
has a substantial personal and public health burden. To advance the mechanistic …
Testing models of thalamic dysfunction in schizophrenia using neuroimaging
Neural models of schizophrenia have implicated the thalamus in deficits of early sensory
processing and multimodal integration. We have reviewed the existing neuroimaging …
processing and multimodal integration. We have reviewed the existing neuroimaging …
Cerebello-thalamo-cortical hyperconnectivity as a state-independent functional neural signature for psychosis prediction and characterization
Understanding the fundamental alterations in brain functioning that lead to psychotic
disorders remains a major challenge in clinical neuroscience. In particular, it is unknown …
disorders remains a major challenge in clinical neuroscience. In particular, it is unknown …
Thalamocortical connectivity and its relationship with symptoms and cognition across the psychosis continuum
BackgroundCoordination between the thalamus and cortex is necessary for efficient
processing of sensory information and appears disrupted in schizophrenia. The significance …
processing of sensory information and appears disrupted in schizophrenia. The significance …