Ubiquitous expression of the calcitonin-i gene in multiple tissues in response to sepsis

B Müller, JC White, ES Nylén… - The Journal of …, 2001 - academic.oup.com
Calcitonin precursors (CTpr), including procalcitonin, are important markers and also
potentially harmful mediators in response to microbial infections. The source and function of …

In Vitro and in Vivo Calcitonin I Gene Expression in Parenchymal Cells: A Novel Product of Human Adipose Tissue

P Linscheid, D Seboek, ES Nylen, I Langer… - …, 2003 - academic.oup.com
Circulating levels of calcitonin precursors (CTpr), including procalcitonin (ProCT), increase
up to several thousand-fold in human sepsis, and immunoneutralization improves survival in …

Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors

KL Becker, ES Nylen, JC White, B Muller… - The Journal of …, 2004 - academic.oup.com
Calcitonin (CT) is a hormone that received its name because of its secretion in response to
induced hypercalcemia and its hypocalcemic effect (1). It was shown to originate from the …

Procalcitonin and CGRP-I mRNA expression in various human tissues

S Russwurm, I Stonans, E Stonane, M Wiederhold… - Shock, 2001 - journals.lww.com
Abstract mdash;: Procalcitonin (PCT) is a highly sensitive and specific marker of systemic
bacterial infection and sepsis. In contrast to its diagnostic significance, the cellular sources of …

Production of procalcitonin (PCT) in non-thyroidal tissue after LPS injection

NG Morgenthaler, J Struck… - Hormone and …, 2003 - thieme-connect.com
Procalcitonin (PCT) is one of the precursors in the synthesis of calcitonin in thyroidal C-cells
and other neuroendocrine cells. PCT, among other calcitonin precursors, is elevated in the …

Procalcitonin expression in human peripheral blood mononuclear cells and its modulation by lipopolysaccharides and sepsis-related cytokines in vitro

M Oberhoffer, I Stonans, S Russwurm… - Journal of laboratory …, 1999 - Elsevier
Procalcitonin (PCT), the precursor of calcitonin, was recently put forward as a diagnostic
marker of systemic bacterial infection and sepsis. The major PCT production site in sepsis …

Isolation and characterization of serum procalcitonin from patients with sepsis

W Weglöhner, J Struck, C Fischer-Schulz… - Peptides, 2001 - Elsevier
Procalcitonin (PCT) is one of the precursors in the synthesis of calcitonin in thyroidal C-cells
and other neuroendocrine cells. PCT and other calcitonin precursors are elevated in the …

Procalcitonin's role in the sepsis cascade. Is procalcitonin a sepsis marker or mediator?

AA Dahaba, H Metzler - Minerva anestesiologica, 2009 - pubmed.ncbi.nlm.nih.gov
PCT is a 116-amino acid polypeptide glycoprotein that is ubiquitously expressed from
various extrathyroid neuroendocrine tissues during bacterial infection. PCT was shown to …

Serum calcitonin precursors in sepsis and systemic inflammation

KT Whang, PM Steinwald, JC White… - The Journal of …, 1998 - academic.oup.com
High serum levels of the calcitonin (CT) prohormone, procalcitonin (pro-CT), and its
component peptides occur in systemic inflammation and sepsis. Using two different assays …

Procalcitonin and proinflammatory cytokine interactions in sepsis

KT Whang, SD Vath, KL Becker, RH Snider, ES Nylen… - Shock, 2000 - journals.lww.com
Abstract mdash;: Immunoneutralization of procalcitonin (ProCT), a putative mediator of
sepsis, has been shown to increase survival in an animal model of sepsis. To better …