Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

P Klein, R Dingledine, E Aronica, C Bernard… - …, 2018 - Wiley Online Library
The most common forms of acquired epilepsies arise following acute brain insults such as
traumatic brain injury, stroke, or central nervous system infections. Treatment is effective for …

[HTML][HTML] Epilepsy related to traumatic brain injury

A Pitkänen, R Immonen - Neurotherapeutics, 2014 - Elsevier
Post-traumatic epilepsy accounts for 10–20% of symptomatic epilepsy in the general
population and 5% of all epilepsy. During the last decade, an increasing number of …

Post-traumatic epilepsy and comorbidities: advanced models, molecular mechanisms, biomarkers, and novel therapeutic interventions

VM Golub, DS Reddy - Pharmacological reviews, 2022 - ASPET
Post-traumatic epilepsy (PTE) is one of the most devastating long-term, network
consequences of traumatic brain injury (TBI). There is currently no approved treatment that …

Novel therapeutic approaches for disease-modification of epileptogenesis for curing epilepsy

BL Clossen, DS Reddy - Biochimica et Biophysica Acta (BBA)-Molecular …, 2017 - Elsevier
This article describes the recent advances in epileptogenesis and novel therapeutic
approaches for the prevention of epilepsy, with a special emphasis on the pharmacological …

Epileptogenesis in experimental models

A Pitkänen, I Kharatishvili, H Karhunen, K Lukasiuk… - …, 2007 - Wiley Online Library
Epileptogenesis refers to a phenomenon in which the brain undergoes molecular and
cellular alterations after a brain‐damaging insult, which increase its excitability and …

Epilepsy after brain insult: targeting epileptogenesis

ST Herman - Neurology, 2002 - AAN Enterprises
Seizures and epilepsy are common sequelae of acute brain insults such as stroke, traumatic
brain injury, and central nervous system infections. Early, or acute symptomatic, seizures …

Posttraumatic epilepsy: the endophenotypes of a human model of epileptogenesis

R Diaz‐Arrastia, MA Agostini, CJ Madden… - …, 2009 - Wiley Online Library
Posttraumatic epilepsy is a common complication of traumatic brain injury (TBI), occurring in
up to 15–20% of patients with severe brain trauma. Trauma accounts for approximately 5 …

[HTML][HTML] Traumatic brain injury and epilepsy: underlying mechanisms leading to seizure

BP Lucke-Wold, L Nguyen, RC Turner, AF Logsdon… - Seizure, 2015 - Elsevier
Post-traumatic epilepsy continues to be a major concern for those experiencing traumatic
brain injury. Post-traumatic epilepsy accounts for 10–20% of epilepsy cases in the general …

Prevention or modification of epileptogenesis after brain insults: experimental approaches and translational research

W Löscher, C Brandt - Pharmacological reviews, 2010 - ASPET
Diverse brain insults, including traumatic brain injury, stroke, infections, tumors,
neurodegenerative diseases, and prolonged acute symptomatic seizures, such as complex …

Molecular and cellular basis of epileptogenesis in symptomatic epilepsy

A Pitkänen, K Lukasiuk - Epilepsy & behavior, 2009 - Elsevier
Epileptogenesis refers to a process in which an initial brain-damaging insult triggers a
cascade of molecular and cellular changes that eventually lead to the occurrence of …