Bench-to-bedside review: oxygen as a drug
H Bitterman - Critical Care, 2009 - Springer
Oxygen is one of the most commonly used therapeutic agents. Injudicious use of oxygen at
high partial pressures (hyperoxia) for unproven indications, its known toxic potential, and the …
high partial pressures (hyperoxia) for unproven indications, its known toxic potential, and the …
Supplementary oxygen for nonhypoxemic patients: O2 much of a good thing?
Supplementary oxygen is routinely administered to patients, even those with adequate
oxygen saturations, in the belief that it increases oxygen delivery. But oxygen delivery …
oxygen saturations, in the belief that it increases oxygen delivery. But oxygen delivery …
Bench-to-bedside review: the effects of hyperoxia during critical illness
Oxygen administration is uniformly used in emergency and intensive care medicine and has
life-saving potential in critical conditions. However, excessive oxygenation also has …
life-saving potential in critical conditions. However, excessive oxygenation also has …
Hemodynamic effects of acute hyperoxia: systematic review and meta-analysis
B Smit, YM Smulders, JC van der Wouden… - Critical Care, 2018 - Springer
Background In clinical practice, oxygen is generally administered to patients with the
intention of increasing oxygen delivery. Supplemental oxygen may, however, cause arterial …
intention of increasing oxygen delivery. Supplemental oxygen may, however, cause arterial …
Highs and lows of hyperoxia: physiological, performance, and clinical aspects
Molecular oxygen (O2) is a vital element in human survival and plays a major role in a
diverse range of biological and physiological processes. Although normobaric hyperoxia …
diverse range of biological and physiological processes. Although normobaric hyperoxia …
Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: insights from the LUNG SAFE study
F Madotto, E Rezoagli, T Pham, M Schmidt… - Critical Care, 2020 - Springer
Background Concerns exist regarding the prevalence and impact of unnecessary oxygen
use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in …
use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in …
Hyperoxia may be beneficial
E Calzia, P Asfar, B Hauser, M Matejovic… - Critical care …, 2010 - journals.lww.com
The current practice of mechanical ventilation comprises the use of the least inspiratory O 2
fraction associated with an arterial O 2 tension of 55 to 80 mm Hg or an arterial hemoglobin …
fraction associated with an arterial O 2 tension of 55 to 80 mm Hg or an arterial hemoglobin …
Reactive oxygen species: toxic molecules or spark of life?
S Magder - Critical care, 2006 - Springer
Increases in reactive oxygen species (ROS) and tissue evidence of oxidative injury are
common in patients with inflammatory processes or tissue injury. This has led to many …
common in patients with inflammatory processes or tissue injury. This has led to many …
Prospective, randomized trial comparing fluids and dobutamine optimization of oxygen delivery in high-risk surgical patients [ISRCTN42445141]
SM Lobo, FR Lobo, CA Polachini, DS Patini… - Critical care, 2006 - Springer
Introduction Preventing perioperative tissue oxygen debt contributes to a better
postoperative recovery. Whether the beneficial effects of fluids and inotropes during …
postoperative recovery. Whether the beneficial effects of fluids and inotropes during …
Hyperoxemia in postsurgical sepsis/septic shock patients is associated with reduced mortality
M Martín-Fernández, M Heredia-Rodríguez… - Critical Care, 2022 - Springer
Background Despite growing interest in treatment strategies that limit oxygen exposure in
ICU patients, no studies have compared conservative oxygen with standard oxygen in …
ICU patients, no studies have compared conservative oxygen with standard oxygen in …