In this review, we explore recombination in two very different virus families that have become
major threats to human health. The Herpesviridae are a large family of pathogenic double …

Viral infection accounts for significant morbidity, mortality, and economic loss worldwide. At
no time in modern history has this been more apparent than it is now given the current …

Nucleases are ubiquitous hydrolytic enzymes that cleave phosphodiester bond of DNA
(DNases), RNA (RNases), or protein-RNA/DNA (phosphodiesterases), within the strand …

Nucleases are ubiquitous hydrolytic enzymes that cleave phosphodiester bond of DNA
(DNases), RNA (RNases), or protein-RNA/DNA (phosphodiesterases), within the strand …

Endonucleases catalyze critical steps in the processing, function, and turnover of many
cellular RNAs. It is, therefore, not surprising that a number of viruses encode endonucleases …

Many DNA viruses concatemerize their genomes as a prerequisite to packaging into
capsids. Concatemerization arises from either replication or homologous recombination …

Recombination in alphaherpesviruses was first described more than sixty years ago. Since
then, different techniques have been used to detect recombination in natural (field) and …

Discovery of antiviral drugs has always been an opportunistic endeavor. Small molecules in
general and nucleoside analogues in particular have led investigators to discover …

Recombination is a pervasive process generating diversity in most viruses. It joins variants
that arise independently within the same molecule, creating new opportunities for viruses to …

Nidoviruses and arenaviruses are the only known RNA viruses encoding a 3'-5'exonuclease
domain (ExoN). The proofreading activity of the ExoN domain has played a key role in the …