Background Understanding the genetic mechanisms underlying the organismal complexity
and origin of novelties during vertebrate history is one of the central goals of evolutionary …

Evolution of organismal complexity and origin of novelties during vertebrate history has
been widely explored in context of both regulation of gene expression and gene duplication …

Background The hypothesis that vertebrates have experienced two ancient, whole genome
duplications (WGDs) is of central interest to evolutionary biology and has been implicated in …

The vertebrate genome contains several closely spaced sets of paralogous genes from
distinct gene families on typically two, three or four different chromosomes (paralogons) …

BACKGROUND: Vertebrate genomes contain extensive intra-genomic conserved synteny,
which is the presence of similar set of genes on two or more chromosomes (paralogons) …

Accumulated evidence indicates strongly that two rounds of whole-genome duplication (2R-
WGD) took place in the vertebrate lineage after its separation from invertebrate chordates; …

The widely popular hypothesis that there were two rounds of genome duplication by
polyploidization early in vertebrate history (the 2R hypothesis) has been difficult to test until …

Background The vertebrate genome often contains closely spaced set of paralogous genes
from distinct gene families on typically two, three or four different chromosomes …

Two rounds of large-scale duplications are thought to have occurred in early vertebrate
ancestry; this is now known as the “2R hypothesis.” They have led to the constitution of …

The hypothesis that the relatively large and complex vertebrate genome was created by two
ancient, whole genome duplications has been hotly debated, but remains unresolved. We …