Strategies to therapeutically target the tumor microenvironment (TME) have emerged as a
promising approach for cancer treatment in recent years due to the critical roles of the TME …

The tumor microenvironment (TME) is being increasingly recognized as a key factor in
multiple stages of disease progression, particularly local resistance, immune-escaping, and …

Cellular and stromal components including tumor cells, immune cells, mesenchymal cells,
cancer-linked fibroblasts, and extracellular matrix, constituent tumor microenvironment …

Genetic alterations drive tumor onset and progression. However, the cross‑talk between
tumor cells and the benign components of the surrounding stroma can also promote the …

Tumor microenvironment (TME) is a host for a complex network of heterogeneous stromal
cells with overlapping or opposing functions depending on the dominant signals within this …

The critical role of tumor microenvironment (TME) in tumor initiation and development has
been well-recognized after more than a century of studies. Numerous therapeutic …

The tumor microenvironment (TME) is an integral part of cancer. Recognition of the essential
nature of the TME in cancer evolution has led to a shift from a tumor cell-centered view of …

Tumors are highly heterogeneous at the patient, tissue, cellular, and molecular levels. This
multi-scale heterogeneity poses significant challenges for effective therapies, which ideally …

It is clear that tumor cells do not act alone but in close interaction with the extracellular matrix
and with stromal cells in the tumor microenvironment (TME). As our understanding of tumor …

Tumorigenesis is a complex and dynamic process involving different cellular and non-
cellular elements composed of tumor microenvironment (TME). The interaction of TME with …