Axonal transport deficits and neurodegenerative diseases
S Millecamps, JP Julien - Nature Reviews Neuroscience, 2013 - nature.com
The intracellular transport of organelles along an axon is crucial for the maintenance and
function of a neuron. Anterograde axonal transport has a role in supplying proteins and …
function of a neuron. Anterograde axonal transport has a role in supplying proteins and …
Role of axonal transport in neurodegenerative diseases
KJ De Vos, AJ Grierson, S Ackerley… - Annu. Rev …, 2008 - annualreviews.org
Many major human neurodegenerative diseases, including Alzheimer's disease,
Parkinson's disease, and amyotrophic lateral sclerosis (ALS), display axonal pathologies …
Parkinson's disease, and amyotrophic lateral sclerosis (ALS), display axonal pathologies …
Axonal transport defects: a common theme in neurodegenerative diseases
A core pathology central to most neurodegenerative diseases is the misfolding, fibrillization
and aggregation of disease proteins to form the hallmark lesions of specific disorders. The …
and aggregation of disease proteins to form the hallmark lesions of specific disorders. The …
[HTML][HTML] Axonal transport defects and neurodegeneration: molecular mechanisms and therapeutic implications
Because of the extremely polarized morphology, the proper functioning of neurons largely
relies on the efficient cargo transport along the axon. Axonal transport defects have been …
relies on the efficient cargo transport along the axon. Axonal transport defects have been …
Disruption of axonal transport in neurodegeneration
SH Berth, TE Lloyd - The Journal of Clinical Investigation, 2023 - Am Soc Clin Investig
Neurons are markedly compartmentalized, which makes them reliant on axonal transport to
maintain their health. Axonal transport is important for anterograde delivery of newly …
maintain their health. Axonal transport is important for anterograde delivery of newly …
Axonal transport: cargo-specific mechanisms of motility and regulation
S Maday, AE Twelvetrees, AJ Moughamian… - Neuron, 2014 - cell.com
Axonal transport is essential for neuronal function, and many neurodevelopmental and
neurodegenerative diseases result from mutations in the axonal transport machinery …
neurodegenerative diseases result from mutations in the axonal transport machinery …
[HTML][HTML] Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?
KJ De Vos, M Hafezparast - Neurobiology of disease, 2017 - Elsevier
Intracellular trafficking of cargoes is an essential process to maintain the structure and
function of all mammalian cell types, but especially of neurons because of their extreme …
function of all mammalian cell types, but especially of neurons because of their extreme …
Axonal transport and neurological disease
Axonal transport is the process whereby motor proteins actively navigate microtubules to
deliver diverse cargoes, such as organelles, from one end of the axon to the other, and is …
deliver diverse cargoes, such as organelles, from one end of the axon to the other, and is …
[HTML][HTML] Axonal transport and neurodegenerative disease
E Chevalier-Larsen, ELF Holzbaur - Biochimica et Biophysica Acta (BBA) …, 2006 - Elsevier
Neurons have extensive processes and communication between those processes and the
cell body is crucial to neuronal function and survival. Thus, neurons are uniquely dependent …
cell body is crucial to neuronal function and survival. Thus, neurons are uniquely dependent …
Retrograde axonal transport: pathways to cell death?
Active transport along the axon is crucial to the neuron. Motor-driven transport supplies the
distal synapse with newly synthesized proteins and lipids, and clears damaged or misfolded …
distal synapse with newly synthesized proteins and lipids, and clears damaged or misfolded …
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