Genome replication is a fundamental biological activity shared by all organisms.
Chromosomal replication proceeds bidirectionally from origins, requiring the loading of two …

Genome replication is a fundamental requirement for the proliferation of all cells. Throughout
the domains of life, conserved DNA replication initiation proteins assemble at specific …

The mechanisms responsible for helicase loading during the initiation of chromosome
replication in bacteria are unclear. Here we report both a positive and a negative …

Initiation and re‐initiation of chromosomal DNA replication in bacteria rely on divergent
multiprotein assemblies, which direct the functional delivery of the replicative helicase on …

Bidirectional DNA replication from a chromosome origin requires the asymmetric loading of
two helicases, one for each replisome. Our understanding of the molecular mechanisms …

The homotetrameric DnaD protein is essential in low G+ C content gram positive bacteria
and is involved in replication initiation at oriC and re-start of collapsed replication forks. It …

Genome duplication is essential for cell proliferation, and DNA synthesis is generally
initiated by dedicated replication proteins at specific loci termed origins. In bacteria, the …

Delivery of the replicative helicase onto DNA is an essential step in the initiation of
replication. In bacteria, DnaC (in Escherichia coli) and DnaI (in Bacillus subtilis) are …

ABSTRACT The Bacillus subtilis DnaI, DnaB and DnaD proteins load the replicative ring
helicase DnaC onto DNA during priming of DNA replication. Here we show that DnaI …

The replicative DNA helicase translocates on single-stranded DNA to drive replication forks
during chromosome replication. In most bacteria the ubiquitous replicative helicase, DnaB …