Transient cognitive impairment in epilepsy

S Landi, L Petrucco, F Sicca, GM Ratto - Frontiers in Molecular …, 2019 - frontiersin.org
Impairments of the dialog between excitation and inhibition (E/I) is commonly associated to
neuropsychiatric disorders like autism, bipolar disorders and epilepsy. Moderate levels of …

Persistent aberrant cortical phase–amplitude coupling following seizure treatment in absence epilepsy models

A Maheshwari, A Akbar, M Wang… - The Journal of …, 2017 - Wiley Online Library
Key points In two monogenic models of absence epilepsy, interictal beta/gamma power is
augmented in homozygous stargazer (stg/stg) but not homozygous tottering (tg/tg) mice …

Inhibiting epileptiform activity in cognitive disorders: possibilities for a novel therapeutic approach

AA Horvath, EA Csernus, S Lality… - Frontiers in …, 2020 - frontiersin.org
Cognitive impairment is a common and seriously debilitating symptom of various mental and
neurological disorders including autism, attention deficit hyperactivity disorder, multiple …

A mechanistic appraisal of cognitive dysfunction in epilepsy

RAB Badawy, KA Johnson, MJ Cook… - … & Biobehavioral Reviews, 2012 - Elsevier
A strong relationship between the clinical characteristics of epilepsy and the nature of
cognitive impairments associated with the condition has been found, but the nature of this …

Cognitive impairment in epilepsy: the role of network abnormalities

GL Holmes - Epileptic Disorders, 2015 - Wiley Online Library
The challenges to individuals with epilepsy extend far beyond the seizures. Co‐morbidities
in epilepsy are very common and are often more problematic to individuals than the seizures …

Mechanisms for cognitive impairment in epilepsy: moving beyond seizures

MR Khalife, RC Scott, AE Hernan - Frontiers in neurology, 2022 - frontiersin.org
There has been a major emphasis on defining the role of seizures in the causation of
cognitive impairments like memory deficits in epilepsy. Here we focus on an alternative …

Perturbed information processing complexity in experimental epilepsy

W Clawson, B Waked, T Madec, A Ghestem… - Journal of …, 2023 - Soc Neuroscience
Comorbidities, such as cognitive deficits, which often accompany epilepsies, constitute a
basal state, while seizures are rare and transient events. This suggests that neural …

EEG abnormalities as a biomarker for cognitive comorbidities in pharmacoresistant epilepsy

GL Holmes - Epilepsia, 2013 - Wiley Online Library
Cognitive impairment is a common and often devastating comorbidity of pharmacoresistent
epilepsy. The cognitive comorbidity can be both chronic, primarily due to the underlying …

Epilepsy as a spectrum disorder: implications from novel clinical and basic neuroscience

FE Jensen - Epilepsia, 2011 - Wiley Online Library
Epilepsy is increasingly recognized as a disease that reaches well beyond seizures.
Cognitive and psychiatric impairment affect half of all epilepsy patients, and to date there are …

Integrative properties and transfer function of cortical neurons initiating absence seizures in a rat genetic model

MS Williams, T Altwegg‐Boussac… - The Journal of …, 2016 - Wiley Online Library
Key points Absence seizures are accompanied by spike‐and‐wave discharges in cortical
electroencephalograms. These complex paroxysmal activities, affecting the thalamocortical …