Beyond excitation/inhibition imbalance in multidimensional models of neural circuit changes in brain disorders
A leading theory holds that neurodevelopmental brain disorders arise from imbalances in
excitatory and inhibitory (E/I) brain circuitry. However, it is unclear whether this one …
excitatory and inhibitory (E/I) brain circuitry. However, it is unclear whether this one …
Cortical excitation: inhibition imbalance causes abnormal brain network dynamics as observed in neurodevelopmental disorders
Abnormal brain development manifests itself at different spatial scales. However, whether
abnormalities at the cellular level can be diagnosed from network activity measured with …
abnormalities at the cellular level can be diagnosed from network activity measured with …
Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex
APF Domanski, SA Booker, DJA Wyllie… - Nature …, 2019 - nature.com
Sensory hypersensitivity is a common and debilitating feature of neurodevelopmental
disorders such as Fragile X Syndrome (FXS). How developmental changes in neuronal …
disorders such as Fragile X Syndrome (FXS). How developmental changes in neuronal …
Imbalance of neocortical excitation and inhibition and altered UP states reflect network hyperexcitability in the mouse model of fragile X syndrome
JR Gibson, AF Bartley, SA Hays… - Journal of …, 2008 - journals.physiology.org
Despite the pronounced neurological deficits associated with mental retardation and autism,
it is unknown if altered neocortical circuit function occurs in these prevalent disorders. Here …
it is unknown if altered neocortical circuit function occurs in these prevalent disorders. Here …
[HTML][HTML] Normal CA1 place fields but discoordinated network discharge in a Fmr1-null mouse model of fragile X syndrome
Silence of FMR1 causes loss of fragile X mental retardation protein (FMRP) and
dysregulated translation at synapses, resulting in the intellectual disability and autistic …
dysregulated translation at synapses, resulting in the intellectual disability and autistic …
Spontaneous Activity Patterns Are Altered in the Developing Visual Cortex of the Fmr1 Knockout Mouse
JE Cheyne, N Zabouri, D Baddeley… - Frontiers in Neural …, 2019 - frontiersin.org
Fragile X syndrome (FXS) is the most prevalent inherited cause of autism and is
accompanied by behavioral and sensory deficits. Errors in the wiring of the brain during …
accompanied by behavioral and sensory deficits. Errors in the wiring of the brain during …
Hyperexcitability and homeostasis in fragile X syndrome
Fragile X Syndrome (FXS) is a leading inherited cause of autism and intellectual disability,
resulting from a mutation in the FMR1 gene and subsequent loss of its protein product …
resulting from a mutation in the FMR1 gene and subsequent loss of its protein product …
Circuit level defects in the developing neocortex of Fragile X mice
JT Gonçalves, JE Anstey, P Golshani… - Nature …, 2013 - nature.com
Subtle alterations in how cortical network dynamics are modulated by different behavioral
states could disrupt normal brain function and underlie symptoms of neuropsychiatric …
states could disrupt normal brain function and underlie symptoms of neuropsychiatric …
Cell-type specific channelopathies in the prefrontal cortex of the fmr1-/y mouse model of fragile X syndrome
Fragile X syndrome (FXS) is caused by transcriptional silencing of the fmr1 gene resulting in
the loss of fragile X mental retardation protein (FMRP) expression. FXS patients display …
the loss of fragile X mental retardation protein (FMRP) expression. FXS patients display …
Neocortical localization and thalamocortical modulation of neuronal hyperexcitability contribute to Fragile X Syndrome
Abstract Fragile X Syndrome (FXS) is a monogenetic form of intellectual disability and
autism in which well-established knockout (KO) animal models point to neuronal …
autism in which well-established knockout (KO) animal models point to neuronal …