Microglia, the resident macrophages of the CNS, are exquisitely sensitive to brain injury and
disease, altering their morphology and phenotype to adopt a so-called activated state in …

It is well accepted that CNS inflammation has a role in the progression of chronic
neurodegenerative disease, although the mechanisms through which this occurs are still …

One hundred and fifty years have elapsed since the original discovery of the microglial cell
by Virchow. While this cell type has been well studied, the role of microglia in the pathology …

Microglia are resident macrophage-like immune cells in the central nervous system (CNS)
and play a vital role in both physiological and pathological conditions, including restoring …

Microglial cells, the resident macrophage population of the central nervous system (CNS),
actively scan tissue under both normal and pathologic contexts. Their resulting engagement …

Microglia are resident immune cells in the central nervous system (CNS) that originate from
myeloid progenitor cells in the embryonic yolk sac and are maintained independently of …

Microglia, the resident immune cells of the central nervous system (CNS), play an important
role in CNS homeostasis during development, adulthood and ageing. Their phenotype and …

A role for innate immunity in neurodegenerative diseases is now widely accepted, although
debate continues over the relative contributions of these processes to disease progression …

As an integral part of the innate immune system of the brain, resident microglia must react
rapidly to the onset of brain injury and neurological disease. These dynamic cells then …

Microglia are the histiocytes of the central nervous system. These long-lived cells undergo
very little turnover in normal physiological states; however, in pathological conditions …