We monitored the effect on function of the G-protein-coupled receptor (GPCR) rhodopsin
from small, stepwise changes in bilayer thickness induced by cholesterol. Over a range of …

Photoactivation of rhodopsin in lipid bilayers results within milliseconds in a metarhodopsin I
(MI)–metarhodopsin II (MII) equilibrium that is very sensitive to the lipid composition. It has …

G protein-coupled receptors (GPCRs) are essential components of cellular signaling
pathways. They are the targets of many current pharmaceuticals and are postulated to …

Lipid composition of the membrane and rhodopsin packing density strongly modulate the
early steps of the visual response of photoreceptor membranes. In this study, lipid-order and …

Four 20 ns molecular dynamic simulations of rhodopsin embedded in different one-
component lipid bilayers have been carried out to ascertain the importance of membrane …

The ability of photoactivated rhodopsin to achieve the enzymatically active metarhodopsin II
conformation is exquisitely sensitive to bilayer hydrophobic thickness. The sensitivity of …

We considered the issue of whether shifts in the metarhodopsin I (MI)-metarhodopsin II (MII)
equilibrium from lipid composition are fully explicable by differences in bilayer curvature …

A prevalent model for the function of rhodopsin centers on the metarhodopsin I (MI) to
metarhodopsin II (MII) conformational transition as the triggering event for the visual process …

Rhodopsin is a member of a superfamily of G-protein-coupled receptors that transduce
signals across membranes. We used Fourier-transform infrared (FTIR) difference …

Membranes with a high content of polyunsaturated phosphatidylethanolamines (PE)
facilitate formation of metarhodopsin-II (MII), the photointermediate of bovine rhodopsin that …