Differential roles of M1 and M2 microglia in neurodegenerative diseases

Y Tang, W Le - Molecular neurobiology, 2016 - Springer
One of the most striking hallmarks shared by various neurodegenerative diseases, including
Parkinson's disease, Alzheimer's disease (AD), and amyotrophic lateral sclerosis, is …

The role of microglia in the development of neurodegeneration

AR Saitgareeva, KV Bulygin, IF Gareev, OA Beylerli… - Neurological …, 2020 - Springer
Microglia-mediated central nervous system (CNS) inflammation is one of the key features of
various neurodegenerative diseases, including Parkinson's and Alzheimer's diseases. In the …

Pharmacological modulation of functional phenotypes of microglia in neurodegenerative diseases

GJ Song, K Suk - Frontiers in aging neuroscience, 2017 - frontiersin.org
Microglia are the resident innate immune cells of the central nervous system that mediate
brain homeostasis maintenance. Microglia-mediated neuroinflammation is a hallmark …

Microglia phenotypes in aging and neurodegenerative diseases

MY Wendimu, SB Hooks - Cells, 2022 - mdpi.com
Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a
fundamental role in mediating the onset and progression of disease. Microglia, which …

Microglia in neuroinflammation and neurodegeneration: from understanding to therapy

L Muzio, A Viotti, G Martino - Frontiers in neuroscience, 2021 - frontiersin.org
Microglia are the resident macrophages of the central nervous system (CNS) acting as the
first line of defense in the brain by phagocytosing harmful pathogens and cellular debris …

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

HS Kwon, SH Koh - Translational neurodegeneration, 2020 - Springer
Neuroinflammation is associated with neurodegenerative diseases, such as Alzheimer's
disease, Parkinson's disease, and amyotrophic lateral sclerosis. Microglia and astrocytes …

Microglia mediated neuroinflammation in Parkinson's disease

S Isik, B Yeman Kiyak, R Akbayir, R Seyhali, T Arpaci - Cells, 2023 - mdpi.com
Parkinson's Disease (PD) is the second most common neurodegenerative disorder seen,
especially in the elderly. Tremor, shaking, movement problems, and difficulty with balance …

Role of microglia in neurological disorders and their potentials as a therapeutic target

L Du, Y Zhang, Y Chen, J Zhu, Y Yang… - Molecular neurobiology, 2017 - Springer
Microglia are resident macrophage-like immune cells in the central nervous system (CNS)
and play a vital role in both physiological and pathological conditions, including restoring …

Microglia dynamics in aging-related neurobehavioral and neuroinflammatory diseases

N Javanmehr, K Saleki, P Alijanizadeh… - Journal of …, 2022 - Springer
Microglia represent the first line of immune feedback in the brain. Beyond immune
surveillance, they are essential for maintaining brain homeostasis. Recent research has …

Microglia polarization in Alzheimer's disease: mechanisms and a potential therapeutic target

Q Wang, H Yao, W Liu, B Ya, H Cheng… - Frontiers in aging …, 2021 - frontiersin.org
Neuroinflammation regulated by microglia is one of the important factors involved in the
pathogenesis of Alzheimer's disease (AD). Activated microglia exhibited phenotypes termed …