The G-protein coupled receptors (GPCRs) activated by free fatty acids (FFAs) have emerged
as new and exciting drug targets, due to their plausible translation from pharmacology to …

GPR120 is a receptor of unsaturated long-chain fatty acids reported to mediate GLP-1
secretion, insulin sensitization, anti-inflammatory, and anti-obesity effects and is therefore …

Background: The family of G-protein-coupled receptors (GPCRs) serves as the target for
almost a third of currently marketed drugs and provides the predominant mechanism …

Free Fatty Acid receptor 4 (FFA4), also known as GPR120, is a G-protein-coupled receptor
(GPCR) responsive to long-chain fatty acids that is attracting considerable attention as a …

The G protein-coupled receptor 40 (GPR40) also known as free fatty acid receptor 1
(FFAR1) is highly expressed in pancreatic, islet β-cells and responds to endogenous fatty …

GPR40, free fatty acid receptor 1 (FFAR1), is a member of the GPCR superfamily and a
possible target for the treatment of type 2 diabetes. In this work, we conducted a bidirectional …

The free fatty acid 1 receptor (FFA1 or GPR40), which is highly expressed on pancreatic β-
cells and amplifies glucose-stimulated insulin secretion, has emerged as an attractive target …

GPR120 (FFAR4) is a fatty acid sensing G protein coupled receptor (GPCR) that has been
identified as a target for possible treatment of type 2 diabetes. A selective activator of …

FFA1 (GPR40) is a new target for treatment of type 2 diabetes. We recently identified the
potent FFA1 agonist TUG-469 (5). Inspired by the structurally related TAK-875, we explored …

Apart from functioning as an energy source and important structural components of
biological membranes, Free Fatty acids (FFAs) play a key role in the regulation of metabolic …