Hydrogen sulfide is a mediator of cerebral ischemic damage

K Qu, CPLH Chen, B Halliwell, PK Moore, PTH Wong - Stroke, 2006 - Am Heart Assoc
Background and Purpose—We observed recently that elevated plasma cysteine levels are
associated with poor clinical outcome in acute stroke patients. In a rat stroke model, cysteine …

Hydrogen sulfide protects the brain against ischemic reperfusion injury in a transient model of focal cerebral ischemia

S Gheibi, N Aboutaleb, M Khaksari… - Journal of Molecular …, 2014 - Springer
Abstract Hydrogen sulfide (H 2 S), a well-known toxic gas, is regarded as endogenous
neuromodulator and plays multiple roles in the central nervous system under physiological …

Dynamic change of hydrogen sulfide during global cerebral ischemia–reperfusion and its effect in rats

C Ren, A Du, D Li, J Sui, WG Mayhan, H Zhao - Brain research, 2010 - Elsevier
Hydrogen sulfide (H2S) is a gaseous messenger and serves as an important
neuromodulator in central nervous system. In the current study, we investigated the change …

Hydrogen sulfide treatment induces angiogenesis after cerebral ischemia

H Jang, MY Oh, YJ Kim, IY Choi, H Yang… - Journal of …, 2014 - Wiley Online Library
Hydrogen sulfide (H2S) is a potent vasodilator and regulates cardiovascular homeostasis.
Furthermore, H2S has a crucial role in ischemia− reperfusion injuries, especially of the …

Hydrogen sulfide: neurochemistry and neurobiology

K Qu, SW Lee, JS Bian, CM Low, PTH Wong - Neurochemistry international, 2008 - Elsevier
Current evidence suggests that hydrogen sulfide (H2S) plays an important role in brain
functions, probably acting as a neuromodulator as well as an intracellular messenger. In the …

Protective effects of exogenous hydrogen sulfide on neurons of hippocampus in a rat model of brain ischemia

Z Li, Y Wang, Y Xie, Z Yang, T Zhang - Neurochemical Research, 2011 - Springer
Many studies have demonstrated the cytoprotective effects of hydrogen sulfide (H 2 S) in
vitro and/or in vivo ischemic injury. The aim of the current study was to investigate whether …

Thiosulfate mediates cytoprotective effects of hydrogen sulfide against neuronal ischemia

E Marutani, M Yamada, T Ida, K Tokuda… - Journal of the …, 2015 - Am Heart Assoc
Background Hydrogen sulfide (H2S) exhibits protective effects in various disease models
including cerebral ischemia–reperfusion (I/R) injury. Nonetheless, mechanisms and identity …

Hydrogen sulfide ameliorates early brain injury following subarachnoid hemorrhage in rats

Y Cui, X Duan, H Li, B Dang, J Yin, Y Wang… - Molecular …, 2016 - Springer
Increasing studies have demonstrated the neuroprotective effect of hydrogen sulfide (H 2 S)
in central nervous system (CNS) diseases. However, the potential application value of H 2 S …

High plasma cyst (e) ine level may indicate poor clinical outcome in patients with acute stroke: possible involvement of hydrogen sulfide

PTH Wong, K Qu, GN Chimon… - … of Neuropathology & …, 2006 - academic.oup.com
Cysteine is known to cause neuronal cell death and has been reported to be elevated in
brain ischemia, but it has not been studied in clinical stroke. In this study, we correlated …

Hydrogen sulfide therapy in brain diseases: from bench to bedside

J Zhang, Y Ding, Z Wang, Y Kong, R Gao… - Medical gas …, 2017 - journals.lww.com
Hydrogen sulfide (H 2 S) has been recognized and studied for nearly 300 years, but past
researches mainly focus on its toxicity effect. During the past two decades, the majority of …