Objective Neuropathological studies in amyotrophic lateral sclerosis (ALS) have shown a
dissemination in a regional sequence in four anatomically defined patterns. The aim of this …

Background Amyotrophic lateral sclerosis (ALS) is characterized by pronounced clinical
heterogeneity in terms of onset and disease progression. Widespread changes in white …

Objective Damage to the cerebral tissue structural connectivity associated with amyotrophic
lateral sclerosis (ALS), which extends beyond the motor pathways, can be visualised by …

Amyotrophic lateral sclerosis is a progressive neurodegenerative disease that affects upper
and lower motor neurons. Observational and intervention studies can be tracked using …

Previous diffusion tensor imaging (DTI) studies have shown white matter pathology in
amyotrophic lateral sclerosis (ALS), predominantly in the motor pathways. Further these …

Objective: The potential of magnetic resonance imaging (MRI) as a technical biomarker for
cerebral microstructural alterations in neurodegenerative diseases is under investigation. In …

Numerous neuroimaging studies in amyotrophic lateral sclerosis (ALS) have reported links
between structural changes and clinical data; however phenotypic and disease course …

Background There is an ongoing debate whether primary lateral sclerosis (PLS) should be
regarded as an independent disease entity separate from amyotrophic lateral sclerosis …

Background: Histopathological studies of amyotrophic lateral sclerosis (ALS) are of end
stage disease. Diffusion tensor imaging (DTI) provides the opportunity to investigate …

BACKGROUND AND PURPOSE: Diffusion tensor imaging (DTI) allows direct visualization
and volumetric analysis of the corticospinal tract (CST). The purpose of this study was to …