The potential of multiparametric quantitative neuroimaging has been extensively discussed
as a diagnostic tool in amyotrophic lateral sclerosis (ALS). In the past, the integration of …

MRI has emerged as one of several urgently needed candidate disease progression
biomarkers for the neurodegenerative disorder amyotrophic lateral sclerosis (ALS), not least …

Diffusion tensor imaging (DTI) allows the in vivo imaging of pathological white matter
alterations, either with unbiased voxel-wise or hypothesis-guided tract-based analysis …

Diagnosis, stratification and monitoring of disease progression in amyotrophic lateral
sclerosis currently rely on clinical history and examination. The phenotypic heterogeneity of …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease whose diagnosis
depends on the presence of combined lower motor neuron (LMN) and upper motor neuron …

BackgroundEvidence of cerebral degeneration is not apparent on routine brain MRI in
amyotrophic lateral sclerosis (ALS). Texture analysis can detect change in images based on …

Background: With the advances in neuroimaging in amyotrophic lateral sclerosis (ALS), it
has been speculated that multiparametric magnetic resonance imaging (MRI) is capable to …

Background Despite significant advances in quantitative neuroimaging, the diagnosis of
ALS remains clinical and MRI-based biomarkers are not currently used to aid the diagnosis …

Introduction: In the last decade, multiparametric magnetic resonance imaging (MRI) has
achieved tremendous advances in applications to amyotrophic lateral sclerosis (ALS) to …

BACKGROUND AND PURPOSE: The previous studies described phenotype-associated
imaging findings in amyotrophic lateral sclerosis (ALS) with a prior categorization of patients …